[HTML][HTML] The role of adenosine A1 and A2A receptors in the caffeine effect on MDMA-induced DA and 5-HT release in the mouse striatum

AM Górska, K Gołembiowska - Neurotoxicity research, 2015 - Springer
Methylenedioxymethamphetamine (MDMA,“ecstasy”) popular as a designer drug is often
used with caffeine to gain a stronger stimulant effect. MDMA induces 5-HT and DA release …

A role for adenosine A1 receptor blockade in the ability of caffeine to promote MDMA “Ecstasy”-induced striatal dopamine release

N Vanattou-Saïfoudine, A Gossen, A Harkin… - European journal of …, 2011 - Elsevier
Co-administration of caffeine profoundly enhances the acute toxicity of 3, 4
methylenedioxymethamphetamine (MDMA) in rats. The aim of this study was to determine …

[HTML][HTML] Neurochemical and neurotoxic effects of MDMA (ecstasy) and caffeine after chronic combined administration in mice

AM Górska, K Kamińska, A Wawrzczak-Bargieła… - Neurotoxicity …, 2018 - Springer
Abstract MDMA (3, 4-methylenedioxymethamphetamine) is a psychostimulant popular as a
recreational drug because of its effect on mood and social interactions. MDMA acts at …

An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine

C Downey, F Daly, KM O'Boyle - Toxicology in Vitro, 2014 - Elsevier
Methylenedioxymethamphetamine (MDMA, ecstasy) is a popular recreational drug which
causes long-term neurotoxicity and increased risk of fatality. In rats, MDMA toxicity is …

Agonists of A1 and A2A adenosine receptors attenuate methamphetamine-induced overflow of dopamine in rat striatum

K Gołembiowska, A Żylewska - Brain research, 1998 - Elsevier
The effect of adenosine receptor agonists on the release of striatal dopamine (DA), induced
by repeated doses of methamphetamine (MTH), was evaluated. Rats received three …

Caffeine enhances astroglia and microglia reactivity induced by 3, 4-methylenedioxymethamphetamine ('ecstasy') in mouse brain

A Khairnar, A Plumitallo, L Frau, N Schintu… - Neurotoxicity …, 2010 - Springer
Abstract Several reports suggest that 3, 4-methylenedioxymethamphetamine (MDMA)
induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated …

Influence of caffeine on 3, 4‐methylenedioxymethamphetamine‐induced dopaminergic neuron degeneration and neuroinflammation is age‐dependent

L Frau, G Costa, PF Porceddu… - Journal of …, 2016 - Wiley Online Library
Previous studies have demonstrated that caffeine administration to adult mice potentiates
glial activation induced by 3, 4‐methylenedioxymethamphetamine (MDMA). As …

Influence of chronic caffeine on MDMA-induced behavioral and neuroinflammatory response in mice

J Ruiz-Medina, A Pinto-Xavier, M Rodríguez-Arias… - …, 2013 - Springer
Rationale Previous research suggests that chronic daily caffeine administration protects
against brain injury in different animal models of neurodegenerative diseases, such as …

Short-and long-term effects of MDMA (“ecstasy”) on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo

IL Bogen, KH Haug, O Myhre, F Fonnum - Neurochemistry international, 2003 - Elsevier
3, 4-Methylenedioxymethamphetamine (MDMA,“ecstasy”) is a commonly abused drug which
has been shown to be neurotoxic to serotonergic neurons in many species. The exact …

MDMA ('ecstasy') enhances basal acetylcholine release in brain slices of the rat striatum

HS Fischer, G Zernig, DS Schatz… - European Journal of …, 2000 - Wiley Online Library
The pharmacological basis of acute (±)‐MDMA (3, 4‐methylenedioxymethamphetamine)
intoxication still awaits full characterization. According to present knowledge, MDMA …