Galanin peptide family regulation of glucose metabolism

P Fang, M Yu, M Shi, P Bo, Z Zhang - Frontiers in Neuroendocrinology, 2020 - Elsevier
Recent preclinical and clinical studies have indicated that the galanin peptide family may
regulate glucose metabolism and alleviate insulin resistance, which diminishes the …

Galanin and its receptors: a novel strategy for appetite control and obesity therapy

P Fang, M Yu, L Guo, P Bo, Z Zhang, M Shi - Peptides, 2012 - Elsevier
The rapid increase in the prevalence of overweight and obesity is becoming an important
health problem. Overweight and obesity may cause several metabolic complications …

Galanin peptide family as a modulating target for contribution to metabolic syndrome

P Fang, M Yu, M Shi, Z Zhang, Y Sui, L Guo… - General and comparative …, 2012 - Elsevier
Metabolic syndrome (MetS) is defined as abdominal central obesity, atherogenic
dyslipidemia, insulin resistance, glucose intolerance and hypertension. The rapid increasing …

Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats

P Fang, B He, M Yu, M Shi, Y Zhu, Z Zhang… - Biochemical …, 2018 - Elsevier
Although recent results of our and other studies have showed that galanin (GAL) is an
antidiabetic and anti-inflammatory neuropeptide, the molecular mechanism how central GAL …

Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge

EP Zorrilla, M Brennan, V Sabino, X Lu, T Bartfai - Physiology & behavior, 2007 - Elsevier
Galanin, a brain and pancreatic peptide with three receptor subtypes (GALR1, GALR2, and
GALR3), is hypothesized to participate in energy homeostasis and glucoregulation …

Galanin‐like peptide and the regulation of feeding behavior and energy metabolism

K Shiba, H Kageyama, F Takenoya… - The FEBS …, 2010 - Wiley Online Library
The hypothalamic neuropeptides modulate physiological activity via G protein‐coupled
receptors (GPCRs). Galanin‐like peptide (GALP) is a 60 amino acid neuropeptide that was …

Galanin antagonist increases insulin resistance by reducing glucose transporter 4 effect in adipocytes of rats

L Guo, M Shi, L Zhang, G Li, L Zhang, H Shao… - General and …, 2011 - Elsevier
Seeing that galanin increases animal body weight on the conditions of inhibiting insulin
secretion and animals with metabolic disorder of galanin easily suffer from diabetes, we …

[HTML][HTML] Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons

A Abot, A Lucas, T Bautzova, A Bessac, A Fournel… - Molecular …, 2018 - Elsevier
Objective Decreasing duodenal contraction is now considered as a major focus for the
treatment of type 2 diabetes. Therefore, identifying bioactive molecules able to target the …

Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats

L Guo, B He, P Fang, P Bo, Z Zhang - Journal of endocrinological …, 2021 - Springer
Purpose Our and other's studies showed that administration of neuropeptide galanin may
mitigate insulin resistance via promoting glucose transporter 4 (GLUT4) expression and …

Galanin participates in the functional regulation of the diabetic heart

P Fang, J Sun, X Wang, Z Zhang, P Bo, M Shi - Life sciences, 2013 - Elsevier
The diabetic heart is characterized by its impaired ability to utilize glucose. Therapeutic
interventions focusing on reducing insulin resistance and enhancing glucose uptake may …