Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays

AL Paguirigan, DJ Beebe - Bioessays, 2008 - Wiley Online Library
Microscale techniques have been applied to biological assays for nearly two decades, but
haven't been widely integrated as common tools in biological laboratories. The significant …

An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets

H Hufnagel, A Huebner, C Gülch, K Güse, C Abell… - Lab on a Chip, 2009 - pubs.rsc.org
We present a modular system of microfluidic PDMS devices designed to incorporate the
steps necessary for cell biological assays based on mammalian tissue culture 'on-chip'. The …

[HTML][HTML] Microfluidic single-cell manipulation and analysis: Methods and applications

T Luo, L Fan, R Zhu, D Sun - Micromachines, 2019 - mdpi.com
In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

IK Zervantonakis, CR Kothapalli, S Chung, R Sudo… - …, 2011 - pubs.aip.org
Microfluidic devices allow for precise control of the cellular and noncellular
microenvironment at physiologically relevant length-and time-scales. These devices have …

[图书][B] Biological applications of microfluidics

FA Gomez - 2008 - books.google.com
Microfluidics has numerous potential applications in biotechnology, pharmaceuticals, the life
sciences, defense, public health, and agriculture. This book details recent advances in the …

[图书][B] Microfluidic devices for biomedical applications

XJ Li, Y Zhou - 2021 - books.google.com
Microfluidic Devices for Biomedical Applications, Second Edition provides updated
coverage on the fundamentals of microfluidics, while also exploring a wide range of medical …

Single-cell microfluidics: opportunity for bioprocess development

A Grünberger, W Wiechert, D Kohlheyer - Current opinion in biotechnology, 2014 - Elsevier
Highlights•Microfluidics offers unique opportunities for bioprocess development.•
Environmental conditions can be precisely controlled on single-cell level.•Single-cell …

Advances of microfluidics in biomedical engineering

Q Zhong, H Ding, B Gao, Z He… - Advanced materials …, 2019 - Wiley Online Library
As an enabling technique, microfluidic systems have developed rapidly in recent years to
emerge as a powerful tool in the field of biomedical engineering. Microfluidics enables …

Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies

BD Cardoso, EMS Castanheira… - Advanced …, 2023 - Wiley Online Library
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …

Continuous perfusion microfluidic cell culture array for high‐throughput cell‐based assays

PJ Hung, PJ Lee, P Sabounchi, R Lin… - Biotechnology and …, 2005 - Wiley Online Library
We present for the first time a microfluidic cell culture array for long‐term cellular monitoring.
The 10× 10 array could potentially assay 100 different cell‐based experiments in parallel …