Impairment of the prominent tumor suppressor p53, well known for its canonical role as the
“guardian of the genome”, is found in almost half of human cancers. More recently, p53 has …

p53 is well recognized as a potent tumor suppressor. In its classic role, p53 responds to
genotoxic insults by inducing cell cycle exit or programmed cell death to limit the …

The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …

During recent years, it is becoming more and more evident that there is a tight connection
between abnormal differentiation processes and cancer. While cancer and stem cells are …

Since its discovery nearly 40 years ago, p53 has ascended to the forefront of investigated
genes and proteins across diverse research disciplines and is recognized most exclusively …

Among the hundreds of oncogenes and tumor suppressors that have been identified in the
past 50 years, p53 is probably the best characterized; nevertheless, new functions are …

Normal development, tissue homeostasis and regeneration following injury rely on the
proper functions of wide repertoire of stem cells (SCs) persisting during embryonic period …

Most human cancers harbor mutations in the gene encoding p53. As a result, research on
p53 in the past few decades has focused primarily on its role as a tumor suppressor. One …

More than half of human tumors harbor an inactivated p53 tumor-suppressor gene. It is well
accepted that mutant p53 shows an oncogenic gain-of-function (GOF) activity that facilitates …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …