Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
Y Zhao, J Tan, L Zhuang, X Jiang… - Proceedings of the …, 2005 - National Acad Sciences
Inhibitors of histone deacetylases (HDACIs) are a new generation of anticancer agents that
selectively kill tumor cells. However, the molecular basis for their tumor selectivity is not well …
selectively kill tumor cells. However, the molecular basis for their tumor selectivity is not well …
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment
Y Yang, Y Zhao, W Liao, J Yang, L Wu, Z Zheng, Y Yu… - Neoplasia, 2009 - Elsevier
Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and
apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis …
apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis …
Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis
Y Zhang, M Adachi, R Kawamura, K Imai - Cell Death & Differentiation, 2006 - nature.com
Histone deacetylase (HDAC) inhibitors modify transcription of selected genes and
eventually induce apoptosis. However, molecular mechanisms for their proapoptotic activity …
eventually induce apoptosis. However, molecular mechanisms for their proapoptotic activity …
Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity
GM Matthews, A Newbold, RW Johnstone - Advances in cancer research, 2012 - Elsevier
Histone deacetylase inhibitors (HDACi) can elicit a range of biological responses that
impede the growth and/or survival of tumor cells. Depending on the physiological context …
impede the growth and/or survival of tumor cells. Depending on the physiological context …
Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitorinduced apoptosis through positive feedback regulation …
J Tan, L Zhuang, X Jiang, KK Yang, KM Karuturi… - Journal of Biological …, 2006 - ASBMB
The oncogenic retinoblastoma protein (Rb)/E2F pathway links cellular proliferation control to
apoptosis as a fail-safe mechanism to protect aberrant oncogenic transformation. We have …
apoptosis as a fail-safe mechanism to protect aberrant oncogenic transformation. We have …
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells
Y Kang, H Nian, P Rajendran, E Kim… - Cell death & …, 2014 - nature.com
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents,
but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as …
but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as …
[HTML][HTML] Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling
A Heinemann, C Cullinane, R De Paoli-Iseppi… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Histone acetylation marks have an important role in controlling gene expression and are
removed by histone deacetylases (HDACs). These marks are read by bromodomain and …
removed by histone deacetylases (HDACs). These marks are read by bromodomain and …
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma
RK Lindemann, A Newbold… - Proceedings of the …, 2007 - National Acad Sciences
Histone deacetylase inhibitors (HDACi) can elicit a range of biological responses that affect
tumor growth and survival, including inhibition of cell cycle progression, induction of tumor …
tumor growth and survival, including inhibition of cell cycle progression, induction of tumor …
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
MJ Peart, KM Tainton, AA Ruefli, AE Dear, KA Sedelies… - Cancer research, 2003 - AACR
Histone deacetylase inhibitors (HDACIs) are a new class of chemotherapeutic drugs able to
induce tumor cell apoptosis and/or cell cycle arrest; however, the molecular mechanisms …
induce tumor cell apoptosis and/or cell cycle arrest; however, the molecular mechanisms …
Induction of apoptosis in BCR/ABL+ cells by histone deacetylase inhibitors involves reciprocal effects on the RAF/MEK/ERK and JNK pathways
C Yu, M Subler, M Rahmani, E Reese… - Cancer biology & …, 2003 - Taylor & Francis
Signal transduction events regulating induction of apoptosis by the histone deacetylase
inhibitors (HDIs) sodium butyrate (SB) and SAHA have been examined in Bcr/Abl+ human …
inhibitors (HDIs) sodium butyrate (SB) and SAHA have been examined in Bcr/Abl+ human …