Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA
P Upadhyaya, SJ Sturla, N Tretyakova… - Chemical research in …, 2003 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a metabolite of the tobacco specific
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
Quantification of DNA Lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in mammalian cells
Quantitative measurement of DNA adducts in carcinogen-exposed cells provides the
information about the frequency of formation and the rate of removal of DNA lesions in vivo …
information about the frequency of formation and the rate of removal of DNA lesions in vivo …
Identification of O2-Substituted Pyrimidine Adducts Formed in Reactions of 4-(Acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(Acetoxymethylnitros …
SS Hecht, PW Villalta, SJ Sturla, G Cheng… - Chemical research in …, 2004 - ACS Publications
Metabolic hydroxylation of the methyl group of the tobacco specific carcinogen 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4 …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4 …
Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated …
M Wang, G Cheng, SJ Sturla, Y Shi… - Chemical research in …, 2003 - ACS Publications
The tobacco specific carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …
The Pyridyloxobutyl DNA Adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]guanine, Is Detected in Tissues from 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone-treated A/J Mice
NM Thomson, PM Kenney… - Chemical research in …, 2003 - ACS Publications
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
S Zhang, M Wang, PW Villalta… - Chemical research in …, 2009 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and
its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are potent pulmonary …
its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are potent pulmonary …
Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific …
P Upadhyaya, BR Lindgren, SS Hecht - Drug Metabolism and Disposition, 2009 - ASPET
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
lung carcinogen in rats and may be a cause of lung cancer in smokers. NNK is metabolized …
lung carcinogen in rats and may be a cause of lung cancer in smokers. NNK is metabolized …
Analysis and identification of 2′-deoxyadenosine-derived adducts in lung and liver DNA of F-344 rats treated with the tobacco-specific carcinogen 4 …
ES Carlson, P Upadhyaya, PW Villalta… - Chemical research in …, 2018 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are carcinogenic in animal models and …
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are carcinogenic in animal models and …
Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its …
P Upadhyaya, S Kalscheuer, JB Hochalter… - Chemical research in …, 2008 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in …
potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in …
Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of …
Y Lao, N Yu, F Kassie, PW Villalta… - Chemical research in …, 2007 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) and its metabolite, 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, 2) are both potent pulmonary …
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, 2) are both potent pulmonary …