α-Acetoxy-N-nitrosopyrrolidine (α-acetoxyNPYR) is a stable precursor to α-hydroxyNPYR,
the initial product of metabolism and proposed proximate carcinogen of N-nitrosopyrrolidine …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific lung carcinogen
which may play an important role as a cause of lung cancer in smokers. NNK is extensively …

O 6-(Carboxymethyl)-2 '-deoxyguanosine (O 6-CMdG) is formed in DNA by nitrosated
glycine derivatives and appears to be nonrepairable by O 6-alkylguanine transferases. O 6 …

Metabolic activation of the carcinogenic tobacco-specific N-nitrosamines leads to the
formation of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts. We recently …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent pulmonary carcinogen in
rodents and is believed to be a causative factor for lung cancer in smokers. NNK also may …

The present paper reports about an immunocytochemical inventory of the cell types involved
in the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3 …

Reaction of 2 '-deoxyguanosine 3 '-monophosphate with mixtures of the benzene
metabolites p-benzoquinone (p-BQ) and hydroquinone (HQ) in an aqueous solution at pH …

4-Hydroxy-2-nonenal (HNE), a major electrophilic byproduct of lipid peroxidation, is
mutagenic and cytotoxic. The two pairs of HNE-derived diastereomeric 1, N 2 …

The effect of nicotine on the metabolism of the tobacco-specific nitrosamine 4-
(methylnitrosamlno)-1-(3-pyridyl)-1-butanone (NNK) was studied in rats.[1-14C] NNK was sc …

The mechanism by which environmentally prevalent N-nitrosodiethanolamine (NDELA) and
related 2-hydroxyethyl-or other β-oxidized nitrosamines initiate the carcinogenic process …