Abstract Iodine-131‑labeled monoiodohypericin (131I‑Hyp) is a necrosis avid compound
used as a complementary anticancer agent. Herein, the biodistribution in rats with re …

Malignant tumor, the leading cause of death worldwide, poses a serious threat to human
health. For decades, natural product has been proven to be an essential source for novel …

Translational medicine pursues the conversion of scientific discovery into human health
improvement. It aims to establish strategies for diagnosis and treatment of diseases. Cancer …

Vinorelbine (NVB) is a semi-synthetic vinca alkaloid that is approved for the clinical therapy
of lung cancer. However, the clinical application of NVB was limited because of the …

Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer
(NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal …

Radiolabeled peptides belong to a highly specific group of radiotracers used in oncology,
particularly for diagnostics and cancer therapy. With the notable advantages of high binding …

Shikonin (SHK) is a pleiotropic agent with remarkable cell growth inhibition activity against
various cancer types, especially non–small cell lung cancer (NSCLC), but its molecular …

2-or 6-(1-hydroxyiminoalkyl)-5, 8-dimethoxy-1, 4-naphthoquinone (2-or 6-hyim-DMNQ)
derived from the roots of Lithospermum erythrorhizon was synthesized for the evaluation of …

Resistance to platinum in tumor tissue is a considerable barrier against effective lung cancer
treatment. Radionuclide therapy is the primary adjuvant treatment, however, the toxic side …

Tanshinone IIA (TSIIA), a multi-pharmaceutical compound, has been demonstrated to have
anti-tumor properties. This study explores the potential regulatory mechanism of TSIIA on …