Multi-targeting of virulence factors of P. aeruginosa by β-lactam antibiotics to combat antimicrobial resistance

FA Qais, N Parveen, I Ahmad, FM Husain… - Journal of …, 2023 - Taylor & Francis
Antimicrobial resistance poses a significant challenge to public health, especially in
developing countries, due to a substantial rise in bacterial resistance. This situation has …

[HTML][HTML] Antimycobacterial Drugs as a Novel Strategy to Inhibit Pseudomonas aeruginosa Virulence Factors and Combat Antibiotic Resistance: A Molecular …

R Anwer - Microbiology Research, 2024 - mdpi.com
Antimicrobial resistance poses a severe threat, particularly in developing countries where
the ready availability of drugs and increased consumption lead to improper antibiotic usage …

A review of chemical signaling pathways in the quorum sensing circuit of Pseudomonas aeruginosa

K Vadakkan, AK Ngangbam, K Sathishkumar… - International Journal of …, 2023 - Elsevier
Pseudomonas aeruginosa, an increasingly common competitive and biofilm organism in
healthcare infection with sophisticated, interlinked and hierarchic quorum systems (Las, Rhl …

[HTML][HTML] Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions

L Zhong, V Ravichandran, N Zhang, H Wang… - International journal of …, 2020 - mdpi.com
Natural products play vital roles against infectious diseases since ancient times and most
drugs in use today are derived from natural sources. Worldwide, multi-drug resistance …

Unveiling the potential of recently FDA-approved drugs as quorum sensing inhibitors against P. Aeruginosa using high-performance computational techniques

D Dey, A Kumar - Journal of Biomolecular Structure and Dynamics, 2024 - Taylor & Francis
Through cell-to-cell communication, activation of efflux pumps, formation of biofilms, and
other mechanisms, pseudomonas aeruginosa's quorum sensing systems (QSS), notably the …

Anti-quorum sensing potential of ketoprofen and its derivatives against Pseudomonas aeruginosa: insights to in silico and in vitro studies

AS Tajani, E Jangi, M Davodi, S Golmakaniyoon… - Archives of …, 2021 - Springer
Antibiotics are usually used for the treatment of bacterial infections, but multidrug-resistant
strains are a phenomenon that has been growing at an increasing rate worldwide. Thus …

Targeting the Pseudomonas aeruginosa quorum sensing system to inhibit virulence factors and eradicate biofilm formation using AHL-analogue phytochemicals

RP Shastry, CS Abhinand - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Quorum sensing plays a major role in the expression of virulence and development of
biofilm in the human pathogen Pseudomonas aeruginosa. Natural compounds are well …

[HTML][HTML] The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Q Li, S Mao, H Wang, X Ye - Marine Drugs, 2022 - mdpi.com
The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic
activity is one of the important inducements for bacteria to develop drug resistance. Bacteria …

Computational screening of natural compounds as putative quorum sensing inhibitors targeting drug resistance bacteria: Molecular docking and molecular dynamics …

K Chaieb, B Kouidhi, SB Hosawi… - Computers in Biology …, 2022 - Elsevier
Quorum sensing (QS) is a bacterial communication strategy controlling cells density, biofilm
formation, virulence, sporulation, and survival. Since QS is considered a virulence factor in …

Investigation of Pseudomonas aeruginosa quorum-sensing signaling system for identifying multiple inhibitors using molecular docking and structural analysis …

V Soheili, BSF Bazzaz, N Abdollahpour… - Microbial …, 2015 - Elsevier
Pseudomonas aeruginosa is an opportunistic human pathogen and a common Gram-
negative bacterium in hospital-acquired infections. It causes death in many burn victims …