Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa

J Fong, C Zhang, R Yang, ZZ Boo, SK Tan… - Scientific reports, 2018 - nature.com
The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies
that would mitigate the increase of classical resistance mechanism. Many bacteria employ …

Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors

E Kalaiarasan, K Thirumalaswamy, BN Harish… - Microbial …, 2017 - Elsevier
Antimicrobial therapy against extensively drug-resistant (XDR) P. aeruginosa biofilms is less
efficient compared to the treatment of equal bacterial counts of free-floating planktonic cells …

Interfering with bacterial quorum sensing

K Reuter, A Steinbach, V Helms - Perspectives in Medicinal …, 2016 - journals.sagepub.com
Quorum sensing (QS) describes the exchange of chemical signals in bacterial populations
to adjust the bacterial phenotypes according to the density of bacterial cells. This serves to …

Drugs with new lease of life as quorum sensing inhibitors: for combating MDR Acinetobacter baumannii infections

NM Seleem, HK Abd El Latif, MA Shaldam… - European Journal of …, 2020 - Springer
The emergence of multidrug-resistant (MDR) strains is a major health problem worldwide.
There is an urgent need for novel strategies to combat bacterial infections caused by MDR …

Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico …

S Hnamte, P Parasuraman, S Ranganathan… - Microbial …, 2019 - Elsevier
Quorum sensing (QS) is the cell density dependent communication network which
coordinates the production of pathogenic determinants in majority of pathogenic bacteria …

Assessing the Molecular Targets and Mode of Action of Furanone C-30 on Pseudomonas aeruginosa Quorum Sensing

V Markus, K Golberg, K Teralı, N Ozer… - Molecules, 2021 - mdpi.com
Quorum sensing (QS), a sophisticated system of bacterial communication that depends on
population density, is employed by many pathogenic bacteria to regulate virulence. In view …

Alternative strategies to regulate quorum sensing and biofilm formation of pathogenic Pseudomonas by quorum sensing inhibitors of diverse origins

P Sankar Ganesh, V Ravishankar Rai - Biotechnological Applications of …, 2018 - Springer
Pathogenic Pseudomonas species produce virulence elements and form biofilm through
quorum sensing (QS) system. Clinical infections caused by Pseudomonas aeruginosa are …

Impact of Pseudomonas aeruginosa quorum sensing signaling molecules on adhesion and inflammatory markers in endothelial cells

C Curutiu, F Iordache, V Lazar… - Beilstein Journal of …, 2018 - beilstein-journals.org
Pseudomonas aeruginosa relies on the quorum sensing (QS) signaling system as a central
regulator mechanism of virulence expression that contributes to the formation and …

Inhibition of quorum sensing and biofilm formation by synthetic quorum signal analogues in Pseudomonas aeruginosa

SK Kim, CJ Kim, JY Yoon, JH Lee - … and Biotechnology Letters, 2011 - koreascience.kr
Pseudomonas aeruginosa is an opportunistic pathogen that causes various infections on
urinary track, cornea, respiratory track, and burn wound site, and mainly relies on quorum …

An innovative role for luteolin as a natural quorum sensing inhibitor in Pseudomonas aeruginosa

YF Geng, C Yang, Y Zhang, SN Tao, J Mei, XC Zhang… - Life sciences, 2021 - Elsevier
Aims The emergence of antibiotic tolerance was a tricky problem in the treatment of chronic
Pseudomonas aeruginosa-infected cystic fibrosis and burn victims. The quorum sensing …