[HTML][HTML] A 3D cell culture system for bioengineering human neuromuscular junctions to model ALS
B Massih, A Veh, M Schenke, S Mungwa… - Frontiers in cell and …, 2023 - frontiersin.org
The signals that coordinate and control movement in vertebrates are transmitted from
motoneurons (MNs) to their target muscle cells at neuromuscular junctions (NMJs). Human …
motoneurons (MNs) to their target muscle cells at neuromuscular junctions (NMJs). Human …
Human neuromuscular junction three-dimensional organoid models and the insight in motor disorders
K Zhang, L Bai, W Xu, C Shen - Journal of Molecular Cell …, 2021 - academic.oup.com
The neuromuscular junction (NMJ), a peripheral synaptic connection between motoneurons
and skeletal muscle fibers, controls movement. Dysregulation of NMJs has been implicated …
and skeletal muscle fibers, controls movement. Dysregulation of NMJs has been implicated …
Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS
Neuromuscular junctions (NMJs) are specialized synapses that mediate communication
between motor neurons and skeletal muscles and are essential for movement. The …
between motor neurons and skeletal muscles and are essential for movement. The …
[HTML][HTML] Modeling neuromuscular junctions in vitro: A review of the current progress employing human induced pluripotent stem cells
LA Patrón, PR August - AIMS Cell and Tissue Engineering, 2018 - aimspress.com
Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder of
undetermined etiology with no effective treatments. Motor weakness and bulbar dysfunction …
undetermined etiology with no effective treatments. Motor weakness and bulbar dysfunction …
[HTML][HTML] Advancements in 2D and 3D In Vitro Models for Studying Neuromuscular Diseases
H Kim, GS Kim, SH Hyun, E Kim - International Journal of Molecular …, 2023 - mdpi.com
Neuromuscular diseases (NMDs) are a genetically or clinically heterogeneous group of
diseases that involve injury or dysfunction of neuromuscular tissue components, including …
diseases that involve injury or dysfunction of neuromuscular tissue components, including …
[HTML][HTML] Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
JD Pereira, DM DuBreuil, AC Devlin, A Held… - Nature …, 2021 - nature.com
Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in
individual human genetic backgrounds and thus for developing precision medicine. Here …
individual human genetic backgrounds and thus for developing precision medicine. Here …
Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality?
SR Thomson, TM Wishart, R Patani… - Journal of …, 2012 - Wiley Online Library
Motor neuron diseases (MND) such as amyotrophic lateral sclerosis and spinal muscular
atrophy are devastating, progressive and ultimately fatal diseases for which there are no …
atrophy are devastating, progressive and ultimately fatal diseases for which there are no …
[HTML][HTML] Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions
RP Rimington, JW Fleming, AJ Capel, PC Wheeler… - Scientific Reports, 2021 - nature.com
Investigations of the human neuromuscular junction (NMJ) have predominately utilised
experimental animals, model organisms, or monolayer cell cultures that fail to represent the …
experimental animals, model organisms, or monolayer cell cultures that fail to represent the …
[HTML][HTML] Self-organizing 3D human trunk neuromuscular organoids
JMF Martins, C Fischer, A Urzi, R Vidal, S Kunz… - Cell stem cell, 2020 - cell.com
Neuromuscular networks assemble during early human embryonic development and are
essential for the control of body movement. Previous neuromuscular junction modeling …
essential for the control of body movement. Previous neuromuscular junction modeling …
[HTML][HTML] Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells
A Urzi, I Lahmann, LVN Nguyen, BR Rost… - Nature …, 2023 - nature.com
The complex neuromuscular network that controls body movements is the target of severe
diseases that result in paralysis and death. Here, we report the development of a robust and …
diseases that result in paralysis and death. Here, we report the development of a robust and …