The signals that coordinate and control movement in vertebrates are transmitted from
motoneurons (MNs) to their target muscle cells at neuromuscular junctions (NMJs). Human …

The neuromuscular junction (NMJ), a peripheral synaptic connection between motoneurons
and skeletal muscle fibers, controls movement. Dysregulation of NMJs has been implicated …

Neuromuscular junctions (NMJs) are specialized synapses that mediate communication
between motor neurons and skeletal muscles and are essential for movement. The …

Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder of
undetermined etiology with no effective treatments. Motor weakness and bulbar dysfunction …

Neuromuscular diseases (NMDs) are a genetically or clinically heterogeneous group of
diseases that involve injury or dysfunction of neuromuscular tissue components, including …

Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in
individual human genetic backgrounds and thus for developing precision medicine. Here …

Motor neuron diseases (MND) such as amyotrophic lateral sclerosis and spinal muscular
atrophy are devastating, progressive and ultimately fatal diseases for which there are no …

Investigations of the human neuromuscular junction (NMJ) have predominately utilised
experimental animals, model organisms, or monolayer cell cultures that fail to represent the …

Neuromuscular networks assemble during early human embryonic development and are
essential for the control of body movement. Previous neuromuscular junction modeling …

The complex neuromuscular network that controls body movements is the target of severe
diseases that result in paralysis and death. Here, we report the development of a robust and …