Human vascularized allografts are perfused through blood vessels composed of cells
(endothelium, pericytes, and smooth muscle cells) that remain largely of graft origin and are …

Endothelial cells form the inner lining of blood vessels. The endothelium displays
remarkable heterogeneity in structure and function. Phenotypic diversity reflects the ability of …

Solid organ transplantation is the only treatment for end-stage organ failure but this life-
saving procedure is limited by immune-mediated rejection of most grafts. Blood vessels …

Allograft arteriopathy is a vascular intimal proliferative process that occurs in all solid organ
transplants and stands as the single most significant obstacle to successful long-term solid …

In organ transplantation, blood borne cells and macromolecules (eg, antibodies) of the host
immune system are brought into direct contact with the endothelial cell lining of graft vessels …

Graft vascular disease (GVD) is the single most important long-term limitation to solid-organ
transplantation. It is a concentric vascular intimal hyperplastic lesion composed of smooth …

Graft rejection remains the major obstacle after vascularized solid organ transplantation.
Endothelial cells, which form the interface between the transplanted graft and the host's …

WHEN hyperacute rejection is prevented, a xenograft becomes subject to acute vascular
rejection, 1 sometimes called “delayed xenograft rejection.” Acute vascular rejection may …

A key manifestation of chronic rejection is an obliterative arteriosclerosis. Myointimal
thickening in the vessel is preceded by an endothelialitis involving accumulation of host …

Graft vessel disease (GVD) is the major limiting factor not only for long-term survival after
heart transplantation (HTx)(Uys & Rose 1984, Schroeder & Hunt 1986, Billingham 1987) but …