Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-
function variants in MTNR1B, which encodes the melatonin receptor MT2, a G protein …

The existence of interindividual variations in G protein-coupled receptor sequences has
been recognized early on. Recent advances in large-scale exon sequencing techniques are …

Genome-wide association studies have revealed that common noncoding variants in
MTNR1B (encoding melatonin receptor 1B, also known as MT2) increase type 2 diabetes …

Abstract Purpose of Review Type 2 diabetes (T2D) is a complex genetic metabolic disorder.
T2D heritability has been estimated around 40–70%. In the last decade, exponential …

Summary Type 2 diabetes (T2D) is a global pandemic. Genome-wide association studies
(GWASs) have identified> 100 genetic variants associated with the disease, including a …

Genome-wide association studies have detected an association between type 2 diabetes
risk and a non-coding SNP located in MTNR1B, the gene encoding melatonin receptor 2 …

The melatonin receptor 1B, encoded by the MTNR1B gene, is a member of the melatonin
receptor family expressed in many tissues, including pancreatic islets (1). Single nucleotide …

The incidence of type 2 diabetes mellitus has markedly increased worldwide over the past
decades. Pancreatic β-cell dysfunction as well as central and peripheral insulin resistance …

The risk of type 2 diabetes (T2D) is increased by abnormalities in sleep quantity and quality,
circadian alignment, and melatonin regulation. A common genetic variant in a receptor for …

Disturbed circadian rhythms have been a risk factor for type 2 diabetes mellitus (T2DM).
Melatonin is the major chronobiotic hormone regulating both circadian rhythm and glucose …