Objective: Our aim of the study was to investigate the expression level and methylation
status of the secreted frizzled-related protein 2 in esophageal squamous cell carcinoma and …

AIM: To investigate the expression and methylation status of the secreted frizzled-related
protein 2 (SFRP2) in esophageal squamous cell carcinoma (ESCC) and explore its role in …

BACKGROUND. The secreted frizzled‐related protein 1 gene (SFRP1) encodes a Wnt/β‐
catenin signaling antagonist and frequently is inactivated by promoter methylation in many …

Hypermethylation of secreted frizzled‐related proteins (SFRP) genes frequently occurs with
several cancers but has not been studied in esophageal adenocarcinoma or its precursor …

Secreted frizzled related protein 1 (SFRP1) is an antagonist of the transmembrane frizzled
receptor, a component of the Wnt signaling pathway, and has been suggested to be a …

The role of secreted frizzled-related protein (SFRP) genes in gastric cancer remains largely
unknown. We determined the frequency and functional significance of SFRPs …

Introduction The secreted frizzled-related protein 1 (SFRP1) gene, as a Wnt signaling
modulator, is frequently inactivated by promoter methylation in many tumors including …

Purpose The aim of this study was to investigate the diagnostic and prognostic significance
of the methylation status of secreted frizzled-related protein 2 (SFRP2) in colorectal cancer …

The role of epigenetic inactivation of secreted frizzled‑related protein 2 (SFRP2) and its
functions in the development of oral squamous cell carcinoma (OSCC) remain to be …

Expression of Secreted frizzled related protein 1 (SFRP1), a recently identified tumor
suppressor gene encoding a WNT signaling antagonist, has been found to be frequently …