Acid Sensing Ion Channels (ASICs) are a family of cation channels expressed principally in
neurons and that are activated by protons. The sensitivity of ASICs to acidosis and their …

Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury
can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels …

Tissue acidosis is a common feature of many painful conditions. Protons are indeed among
the first factors released by injured tissues, inducing a local pH fall that depolarizes …

Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …

Since their molecular cloning in the late 90's, Acid-Sensing Ion Channels (ASICs) have been
shown to be involved in many aspects of nociception, both in peripheral and central …

The history of ASICs began in 1980 with unexpected observation. The concept of highly
selective Na+ current gated by specific receptors for protons was not easily accepted. It took …

Low pH in tissue can evoke pain in animals and humans, and is an important factor in
hyperalgesia. Research has also implicated acidosis in psychiatric and neurological …

Publisher Summary This chapter discusses the structure of acid sensing ionic channels
(ASICs), their response profiles to acid, localization in a subset of sensory neurons, possible …

Acidosis is a noxious condition associated with inflammation, ischaemia or defective acid
containment. As a consequence, acid sensing has evolved as an important property of …

Background Extracellular acidosis is a prominent feature of multiple pathological conditions,
correlating with pain sensation. Acid-sensing ion channels (ASICs), a family of proton-gated …