Background: In the clinical setting, anticancer therapy is routinely administered to stimulate
programmed cell death or “apoptosis.” The goal is to eliminate tumor cells. Whether …

Apoptosis is a cell suicide program that plays a critical role in development and tissue
homeostasis. The ability of cancer cells to evade this programmed cell death (PCD) is a …

Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, eg
chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly …

Defects in apoptosis that evolve during the course of cancer progression not only provide
cancer cells with intrinsic survival advantage, but also provide inherent resistance to …

Defective apoptosis (programmed cell death) represents a major causative factor in the
development and progression of cancer. The ability of tumor cells to evade engagement of …

Apoptotic cell death serves as an important tumor suppressor mechanism at multiple steps
during cancer progression. Equally, engagement of apoptosis represents a potent …

Apoptosis, the cell's intrinsic program to death, plays a central role in physiological growth
control and regulation of tissue homeostasis. Tipping the balance between cell death and …

Defects in apoptosis that evolve during the course of cancer progression not only provide
cancer cells with intrinsic survival advantage, but also provide inherent resistance to …

A common feature of cancer cells is their ability to evade apoptosis as a result of alterations
that block cell death signaling pathways. The extensive research efforts that elucidated …

Resistance towards apoptosis is a key factor for the survival of a malignant cell. Cancer
results if there is too little apoptosis and cells grow faster and live longer than normal cells. In …