Interleukin (IL) 6 has been suggested to be the major cytokine responsible for proliferation of
neoplastic plasma cells in both human myeloma and mouse plasmacytoma. Much of the …

Murine plasmacytomas show a striking dependence on interleukin 6 (IL-6) for their growth in
vitro. Here, we present evidence suggesting that IL-6 also plays an essential role in the in …

To study the potential involvement of IL-6 in the development of plasmacytomas, a number
of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement …

In the present report we demonstrate that the IL-6 gene is expressed in anti-Ig-activated and
neoplastic B cells. After activation with anti-Ig, splenic B cells rapidly expressed IL-6 mRNA …

The biological role of interleukin 6 (IL-6) molecules in human B cell tumorigenesis was
studied by using an episomal expression vector, pHEBoSV-IL6, to introduce stably the …

The authors, and others, clearly have established that interleukin‐6 (IL‐6) is the major
growth factor for human myeloma cells in vitro. It is a critical conceptual point whether or not …

We introduced an IL-6 cDNA expression vector into a murine B cell line, the growth of which
definitely required the presence of exogenous IL-6. The transfected cells secreted …

The role of interleukin 6 (IL-6) in the growth of five multiple myeloma-derived cell lines was
characterized. The U266 and RPMI 8226 cell lines demonstrated increased DNA synthesis …

The growth and differentiation of normal B-cells are under stringent control by complex cell-
cell interactions, including cell-cell contacts and growth-and differentiation factor signalling …

Abstract Interleukin 6 (IL‐6) is a multifunctional cytokine regulating immune response, acute
phase reaction and hematopoiesis. IL‐6 plays a critical role in B cell differentiation to plasma …