Interleukin 6 is essential for in vivo development of B lineage neoplasms.
DM Hilbert, M Kopf, BA Mock, G Köhler… - The Journal of …, 1995 - rupress.org
Interleukin (IL) 6 has been suggested to be the major cytokine responsible for proliferation of
neoplastic plasma cells in both human myeloma and mouse plasmacytoma. Much of the …
neoplastic plasma cells in both human myeloma and mouse plasmacytoma. Much of the …
Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor.
A Vink, P Coulie, G Warnier, JC Renauld… - The Journal of …, 1990 - rupress.org
Murine plasmacytomas show a striking dependence on interleukin 6 (IL-6) for their growth in
vitro. Here, we present evidence suggesting that IL-6 also plays an essential role in the in …
vitro. Here, we present evidence suggesting that IL-6 also plays an essential role in the in …
DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.
T Blankenstein, ZH Qin, WQ Li… - The Journal of …, 1990 - rupress.org
To study the potential involvement of IL-6 in the development of plasmacytomas, a number
of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement …
of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement …
Interleukin 6 gene expression in normal and neoplastic B cells.
GJ Freeman, AS Freedman… - The Journal of …, 1989 - Am Soc Clin Investig
In the present report we demonstrate that the IL-6 gene is expressed in anti-Ig-activated and
neoplastic B cells. After activation with anti-Ig, splenic B cells rapidly expressed IL-6 mRNA …
neoplastic B cells. After activation with anti-Ig, splenic B cells rapidly expressed IL-6 mRNA …
Expression of an exogenous interleukin 6 gene in human Epstein Barr virus B cells confers growth advantage and in vivo tumorigenicity.
The biological role of interleukin 6 (IL-6) molecules in human B cell tumorigenesis was
studied by using an episomal expression vector, pHEBoSV-IL6, to introduce stably the …
studied by using an episomal expression vector, pHEBoSV-IL6, to introduce stably the …
Interleukin‐6 dependence of advanced malignant plasma cell dyscrasias
XG Zhang, R Bataille, J Widjenes, B Klein - Cancer, 1992 - Wiley Online Library
The authors, and others, clearly have established that interleukin‐6 (IL‐6) is the major
growth factor for human myeloma cells in vitro. It is a critical conceptual point whether or not …
growth factor for human myeloma cells in vitro. It is a critical conceptual point whether or not …
Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA.
N Tohyama, H Karasuyama, T Tada - The Journal of experimental …, 1990 - rupress.org
We introduced an IL-6 cDNA expression vector into a murine B cell line, the growth of which
definitely required the presence of exogenous IL-6. The transfected cells secreted …
definitely required the presence of exogenous IL-6. The transfected cells secreted …
Role of interleukin 6 in the growth of myelomaderived cell lines
BA Barut, LI Zon, MK Cochran, SR Paul, D Chauhan… - Leukemia research, 1992 - Elsevier
The role of interleukin 6 (IL-6) in the growth of five multiple myeloma-derived cell lines was
characterized. The U266 and RPMI 8226 cell lines demonstrated increased DNA synthesis …
characterized. The U266 and RPMI 8226 cell lines demonstrated increased DNA synthesis …
IL-6 as a growth factor for human multiple myeloma cells-A short overview
K Nilsson, H Jernberg, M Pettersson - … in B-Cell Neoplasia 1990: Workshop …, 1990 - Springer
The growth and differentiation of normal B-cells are under stringent control by complex cell-
cell interactions, including cell-cell contacts and growth-and differentiation factor signalling …
cell interactions, including cell-cell contacts and growth-and differentiation factor signalling …
Interleukin 6 (IL‐6) and its receptor: their role in plasma cell neoplasias
T Hirano - The International Journal of Cell Cloning, 1991 - Wiley Online Library
Abstract Interleukin 6 (IL‐6) is a multifunctional cytokine regulating immune response, acute
phase reaction and hematopoiesis. IL‐6 plays a critical role in B cell differentiation to plasma …
phase reaction and hematopoiesis. IL‐6 plays a critical role in B cell differentiation to plasma …