Advances in physiology, design and development of novel medications changing the landscape of obesity pharmacotherapy

M Chakhtoura, CS Mantzoros - Metabolism-Clinical and …, 2023 - metabolismjournal.com
As the word has been celebrating innovations and technological achievements during the
last few decades, there has also been a noticeable increase in various non-communicable …

New advances in models and strategies for developing anti-obesity drugs

GW Kim, JE Lin, ES Blomain… - Expert opinion on drug …, 2013 - Taylor & Francis
Introduction: Obesity is a worldwide pandemic. Obesity-related health and economic costs
are staggering. Existing strategies to combat obesity through lifestyle improvements and …

Current options for the pharmacotherapy of obesity

I Gouni-Berthold, HK Berthold - Current Pharmaceutical Design, 2019 - ingentaconnect.com
650 millions of adults are obese worldwide-in the US alone, forty percent of the adults are
obese. Although the obesity pandemic is constantly expanding at very high costs for health …

Central and peripheral molecular targets for antiobesity pharmacotherapy

MA Valentino, JE Lin… - Clinical Pharmacology & …, 2010 - Wiley Online Library
Obesity has emerged as one of the principal worldwide health concerns of the modern era,
and there exists a tremendous unmet clinical need for safe and effective therapies to combat …

New drug targets for the treatment of obesity

AG Powell, CM Apovian… - Clinical pharmacology & …, 2011 - Wiley Online Library
There is a huge void in the current pharmacological treatment options for obesity. This gap is
surprising given the high prevalence and associated costs of obesity. Many factors have …

Search for obesity drugs: targeting central and peripheral pathways

RA K Srivastava, N Srivastava - Current Medicinal Chemistry …, 2004 - ingentaconnect.com
The prevalence of obesity has increased in alarming proportions over the past 10 years and
being recognized as an epidemic. Obesity is now considered as a disease, and is …

Obesity pharmacotherapy: current perspectives and future directions

M Misra - Current Cardiology Reviews, 2013 - ingentaconnect.com
The rising tide of obesity and its related disorders is one of the most pressing health
concerns worldwide, yet existing medicines to combat the problem are disappointingly …

Obesity–an update on the basic pathophysiology and review of recent therapeutic advances

E Gjermeni, AS Kirstein, F Kolbig, M Kirchhof… - Biomolecules, 2021 - mdpi.com
Obesity represents a major public health problem with a prevalence increasing at an
alarming rate worldwide. Continuous intensive efforts to elucidate the complex …

Obesity pharmacotherapy: what is next?

F Colon-Gonzalez, GW Kim, JE Lin… - Molecular aspects of …, 2013 - Elsevier
The increase in obesity in the Unites States and around the world in the last decade is
overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008 …

Obesity drug update: The lost decade?

F Yao, RG MacKenzie - Pharmaceuticals, 2010 - mdpi.com
The growing worldwide obesity epidemic and obesity-related disorders present a huge
unmet medical need for safe and effective anti-obesity medications. The discovery of leptin …