Long-term potentiation in the spinal dorsal horn requires peptidergic C-fibre activation in
animals. Perceptual correlates of long-term potentiation following high-frequency electrical …

Individual differences in pain sensitivity and reactivity are well recognized but the underlying
mechanisms are likely to be diverse. The phenomenon of stress-induced analgesia is well …

Recently, we have shown that neuropathic pain is associated with anxiety-like behaviour in
rats with sciatic nerve lesion. An enhanced pain perception has also been described in …

Acute injury–induced pain can transition to chronic nociplastic pain, which predominantly
affects women. To facilitate studies on the underlying mechanisms of nociplastic pain, we …

Persistent sensitivity to noxious and innocuous somatic stimuli results from peripheral nerve
injury. Following chronic constriction injury (CCI) of the sciatic nerve in the rat, the hind paw …

Mechanical stimulation of the somata of cultured neonatal rat dorsal root ganglia (DRG)
neurons evoked inward cationic currents that displayed distinct properties between different …

Objective. Stressful life events are associated with increased pain severity and chronicity.
However, the mechanism underlying this association remains disputed. Recent animal …

This study examines the contribution of central corticotropin-releasing factor (CRF) to pain
behavior. CRF is the principal modulator of the hypothalamo–pituitary–adrenal (HPA) axis …

Capsaicin modulates animal pain perception, increasing chemosensitive and pressure
thresholds following systemic administration, increasing thermal thresholds following …

The effect of age on hyperalgesia, one of the most common signs of injury, has not been
previously examined in humans. A psychophysical study was conducted in 10 young …