Tumorigenesis is a complex process, and understanding the mechanisms behind
tumorigenesis is key to identifying effective targeted therapies. Prostaglandins are signaling …

Cyclooxygenase-2 (COX-2) is the enzyme primarily responsible for prostaglandin synthesis
in the setting of inflammation. It also can be induced by a variety of agents, including tumor …

Tumor growth and angiogenesis are interdependent. Cyclooxygenase (COX) catalyzes the
synthesis of prostaglandins (PGs) from arachidonic acid. Nonsteroidal antiinflammatory …

The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin
(PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the …

Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially …

Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has
attracted considerable attention recently, due to its role in human cancer biology. Several …

The multistep process of carcinogenesis, which can take many years, provides many
opportunities for intervention to inhibit disease progression. Effective chemoprevention …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Prior to the discovery of cyclooxygenase-2 (COX-2), a beneficial association was shown
between chronic usage of non steroidal anti-inflammatory drugs (NSAIDs), that …

Abstract Cyclooxygenase-1 and-2 (COX-1/2) catalyze the initial step in the formation of
prostaglandins. Very recently their role in carcinogenesis has become more evident. They …