Abstract Cyclooxygenase-1 and-2 (COX-1/2) catalyze the initial step in the formation of
prostaglandins. Very recently their role in carcinogenesis has become more evident. They …

Increased prostaglandin (PG) production is associated with many inflammatory
pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

NSAIDs (non-steroidal anti-inflammatory drugs) prevent colon and other cancers. The fact
that NSAIDs inhibit the eicosanoid pathway prompted mechanistic drug-developmental work …

Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key
positions in important physiologic processes such as immunity, reproduction, and vascular …

The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

For more than a century, inhibition of prostaglandin biosynthesis via inhibition of the fatty
acid cyclooxygenase (COX) has been achieved by non-steroidal anti-inflammatory drugs …

COX-2 is an isoenzyme of cyclooxygenase that is increased in response to growth factors,
cytokines, and other mitogenic stimuli. Upregulation of COX-2 gene expression and …

Angiogenesis is required for multistage carcinogenesis. The inducible enzyme
cyclooxygenase-2 (COX-2) is an important mediator of angiogenesis and tumor growth …

Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …