The cyclo-oxygenase (COX) metabolic pathway and prostaglandin (PG) production appear
to play a causal role in the promotion and progression of human cancers. COX-1 and COX-2 …

The revelation that aspirin and aspirin-like compounds have notableantineo plastic
properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and …

There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon
carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) …

Several types of human tumors overexpress cyclooxygenase (COX)-2 but not COX-1, and
gene knockout transfection experiments demonstrate a central role of COX-2 in …

Carcinogenesis is a multistep process of long-term accumulation of genetic and epigenetic
aberrations at the molecular level. Understanding the mechanisms underlying …

Colorectal cancer is an excellent model for studying cancer prevention by means of
secondary (eg, polypectomy to remove a precursor adenoma) and primary …

It is suggested that nonsteroidal antiinflammatory inhibitors alter the biology of colorectal
carcinogenesis. Cyclooxygenase-2, one of target molecules of these drugs, is reported to be …

Inhibitors of prostaglandin synthesis show great promise as cancer chemopreventive
agents, with efficacy demonstrated in randomized clinical trials. Unfortunately, these agents …

Cyclooxygenase-2 (COX-2), the inducible cyclooxygenase isozyme involved in the
conversion of arachidonic acid (AA) to biologically active prostanoids, has become the …

An expanding body of evidence indicates that downregulation of the cy-clooxygenases (Cox-
1 and Cox-2) will be an important strategy for preventing cancer because cyclooxygenases …