The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

The current use of antineoplastic drugs in human therapy causes a substancial number of
toxic or side effects which consequently lead to a reduction of the amount of drug to be …

Non‐steroidal anti‐inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase
(COX)‐2, are therapeutic groups widely used for the treatment of pain, inflammation and …

The rate-limiting step in arachidonate metabolism is mediated by enzymes known as
cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 …

Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs
(NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of …

Cancer is a leading cause of death worldwide. The expression of COX-2 and prostaglandins
has not only been associated with various types of cancer but is also directly proportional to …

Colorectal cancer (CRC) is one of the most common neoplasia in Western countries and the
second leading cause of cancer-related death. The vast majority of cases belong to sporadic …

Epidemiological studies suggest that aspirin and other nonsteroidal anti-inflammatory drugs
(NSAIDs) reduce the incidence of and mortality from colorectal, gastric, and esophageal …

Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of
prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …