Early experiments performed during 1980s and 1990s using carcinogen-induced rat
intestinal tumor models demonstrated the inhibitory effects of non-steroidal anti-inflammatory …

Radiation therapy has traditionally been the treatment of choice for locally or regionally
advanced cancer, but its therapeutic efficacy is often hindered by limited tolerance of normal …

Most epithelial cancers, including those of the digestive tract, show overexpression of COX-
2, an inducible enzyme controlling prostaglandin synthesis. The upregulation of COX-2 in …

On the basis of the current data and the clinical availability of safe inhibitors, COX-2 is a
perfect target for cancer prevention and therapy. A number of trials are investigating the …

Arachidonic acid metabolism through cyclooxygenase (COX) pathways leads to the
generation of biologically active eicosanoids. Eicosanoid expression levels vary during …

The inducible prostaglandin synthase cyclooxygenase-2 (COX-2) is normally expressed
predominantly in kidney and brain, and also has important roles in reproduction and …

Increased prostaglandins (PGs) are associated with many inflammatory pathophysiological
conditions; and are synthesized from arachidonic acid by either of 2 enzymes …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Cyclooxygenase-2 (COX-2) overexpression is seen in many malignancies including lung
cancer. Elevated tumor prostaglandin E2 (PGE2), a major COX-2 metabolite, levels have …

Lung cancer is the leading cause of cancer death in the USA. Conventional therapy using
chemotherapy, radiation therapy, and a combination of the two, has yielded modest …