Background. There are no approved drug treatments for liver fibrosis and nonalcoholic
steatohepatitis (NASH), an advanced stage of fibrosis which has rapidly become a major …

The development of complex in vitro hepatic systems and artificial liver devices has been
hampered by the lack of reliable sources for relevant cell types, such as hepatic stellate cells …

Liver fibrosis is a global health problem caused by chronic liver injury resulting from various
factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis …

Background/Aims: Wnt/β-catenin pathway is involved in liver fibrosis and microRNAs
(miRNAs) are considered as key regulators of the activation of hepatic stellate cells (HSCs) …

Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for
decreasing mortality is liver transplantation. However, transplant surgery is highly invasive …

Aim: During fibrosis, hepatic stellate cells (HSCs) undergo a complex activation process
characterized by increased proliferation and extracellular matrix deposition. Previous …

Proliferating hepatic stellate cells (HSC s) respond to liver damage by secreting collagens
that form fibrous scar tissue, which can lead to cirrhosis if in appropriately regulated …

Mesenchymal stem cell small extracellular vesicles (MSC-sEVs) are a priority for
researchers because of their role in tissue regeneration. sEVs act as paracrine factors and …

New research published in Nature Communications has confirmed hepatic stellate cells
(HSCs) as key contributors towards liver fibrosis in vivo irrespective of the underlying …

Liver fibrosis is a severe stage of nonalcoholic fatty liver disease (NAFLD), which is closely
associated with the activation of hepatic stellate cells (HSCs) and their interaction with …