Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells
increases inflammatory osteolysis and decreases bone formation, thereby predisposing …

Triple–negative breast cancer (TNBC) is thought to be an estradiol–independent, hormone
therapy–resistant cancer because of lack of estrogen receptor alpha 66 (ERα66). We …

A variety of osteolytic factors have been identified from breast cancer cells leading to
osteolysis, but less is known about which factor plays an essential role in the initiation …

The bones are the most common sites of breast cancer metastasis. Upon arrival within the
bone microenvironment, breast cancer cells coordinate the activities of stromal cells …

Bone metastases are the most common skeletal complication of malignancy. Tumor cells
disrupt normal bone remodeling to promote bone destruction and its associated morbidity. In …

Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to
osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor …

Breast cancer metastases to the bone can lead to a series of bone-related events that
seriously affect the quality of life. Pexmetinib, a novel p38 mitogen-activated protein kinase …

Ethnopharmacological relevance The anti-tumor related diseases of Coptidis Rhizoma
(Huanglian) were correlated with its traditional use of removing damp-heat, clearing internal …

Bone metastases are severely debilitating and have a significant impact on the quality of life
of women with metastatic breast cancer. Treatment options are limited and in order to …

Breast cancer preferentially metastasizes to the skeleton, a hospitable environment that
attracts and allows breast cancer cells to thrive. Growth factors released as bone is …