The effects of mutant Ras proteins on the cell signalome
The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation.
Ras is a key molecule that controls several tumorigenesis-related processes, and mutations …
Ras is a key molecule that controls several tumorigenesis-related processes, and mutations …
RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies
B Fang - Acta biochimica et biophysica Sinica, 2016 - academic.oup.com
Activating mutations of oncogenic RAS genes are frequently detected in human cancers.
The studies in genetically engineered mouse models (GEMMs) reveal that Kras-activating …
The studies in genetically engineered mouse models (GEMMs) reveal that Kras-activating …
RAS isoforms and mutations in cancer at a glance
ABSTRACT RAS proteins (KRAS4A, KRAS4B, NRAS and HRAS) function as GDP–GTP-
regulated binary on-off switches, which regulate cytoplasmic signaling networks that control …
regulated binary on-off switches, which regulate cytoplasmic signaling networks that control …
Emerging strategies to target RAS signaling in human cancer therapy
K Chen, Y Zhang, L Qian, P Wang - Journal of hematology & oncology, 2021 - Springer
Abstract RAS mutations (HRAS, NRAS, and KRAS) are among the most common
oncogenes, and around 19% of patients with cancer harbor RAS mutations. Cells harboring …
oncogenes, and around 19% of patients with cancer harbor RAS mutations. Cells harboring …
RAS oncogenes: weaving a tumorigenic web
Y Pylayeva-Gupta, E Grabocka, D Bar-Sagi - Nature Reviews Cancer, 2011 - nature.com
RAS proteins are essential components of signalling pathways that emanate from cell
surface receptors. Oncogenic activation of these proteins owing to missense mutations is …
surface receptors. Oncogenic activation of these proteins owing to missense mutations is …
RAS-mediated oncogenic signaling pathways in human malignancies
Abnormally activated RAS proteins are the main oncogenic driver that governs the
functioning of major signaling pathways involved in the initiation and development of human …
functioning of major signaling pathways involved in the initiation and development of human …
The role of wild type RAS isoforms in cancer
B Zhou, CJ Der, AD Cox - Seminars in cell & developmental biology, 2016 - Elsevier
Mutationally activated RAS proteins are critical oncogenic drivers in nearly 30% of all human
cancers. As with mutant RAS, the role of wild type RAS proteins in oncogenesis, tumour …
cancers. As with mutant RAS, the role of wild type RAS proteins in oncogenesis, tumour …
Oncogenic Ras and its role in tumor cell invasion and metastasis
PM Campbell, CJ Der - Seminars in cancer biology, 2004 - Elsevier
The processes by which cancer cells leave the tumor and enter adjacent tissue is known as
invasion, whereas metastasis refers to secondary tumor colonization of tissue at a distance …
invasion, whereas metastasis refers to secondary tumor colonization of tissue at a distance …
An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer
O Maertens, K Cichowski - Advances in biological regulation, 2014 - Elsevier
The RAS pathway is one of the most commonly deregulated pathways in human cancer.
Mutations in RAS genes occur in nearly 30% of all human tumors. However in some tumor …
Mutations in RAS genes occur in nearly 30% of all human tumors. However in some tumor …
Increasing complexity of Ras signaling
The initial discovery that ras genes endowed retroviruses with potent carcinogenic
properties and the subsequent determination that mutated ras genes were present in a wide …
properties and the subsequent determination that mutated ras genes were present in a wide …