In-silico modeling and in-vitro studies of 2, 1-benzothiazine-2, 2-dioxide based hydrazone derivatives as α-glucosidase inhibitors.

S Ahmad, S Taj, S Aslam, SG Khan… - Pakistan Journal of …, 2021 - search.ebscohost.com
Diabetes mellitus (DM) is a metabolic disorder characterized by frequent urination, hunger
and high blood sugar level. α-glucosidase inhibitors are considered as a frontline treatment …

Alpha-glucosidase inhibition and molecular docking studies of 1, 2-benzothiazine 1, 1-dioxide based carbohydrazides.

FA Saddique, M Ahmad, UA Ashfaq… - Pakistan journal of …, 2019 - search.ebscohost.com
Diabetes mellitus is a chronic disease in which the infected cells do not have the ability to
produce sufficient amount of insulin that results in the abnormality of carbohydrates …

Synthesis of 1,2,3-benzotriazin-4(3H)-one derivatives as α-glucosidase inhibitor and their in-silico study

Z Khalid, SS Shafqat, HA Ahmad, HM Rehman… - Medicinal Chemistry …, 2022 - Springer
Abstract α-Glucosidase inhibition is considered as an effective strategy for the treatment of
diabetes mellitus. Currently, three α-glucosidase inhibitors are being used as drugs; …

[HTML][HTML] Exploring the therapeutic potential of benzothiazine-pyrazole hybrid molecules against alpha-glucosidase: Pharmacological and molecular modelling based …

S Taj, M Ahmad, A Alshammari, A Alghamdi… - Saudi Journal of …, 2022 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder and a significant health problem all over the
world. The current study elucidates the inhibitory potentials of the benzothiazine-pyrazole …

Synthesis, α‐glucosidase Inhibition, in silico Pharmacokinetic, and Docking Studies Of Thieno[2,3‐b]Quinoline‐Acetamide Derivatives as New Anti‐Diabetic Agents

M Mohammadi‐Khanaposhtani, M Noori… - …, 2022 - Wiley Online Library
In this work, novel anti‐α‐glucosidase agents, thieno [2, 3‐b] quinoline‐acetamide
derivatives 5 a–m have been designed and synthesized. These compounds were evaluated …

Synthesis of novel substituted quinoline derivatives as diabetics II inhibitors and along with their in-silico studies

SK Avula, S Ullah, SA Halim, A Khan, MU Anwar… - Journal of Molecular …, 2023 - Elsevier
In this article, 26 compounds of substituted quinoline derivatives were synthesized and their
α-glucosidase inhibition activity against the α-glucosidase enzyme was investigated. The …

Coumarin linked thiazole derivatives as potential α-glucosidase inhibitors to treat diabetes mellitus

R Ichale, AM Kanhed, A Vora - Molecular Diversity, 2023 - Springer
Diabetes is a leading cause of kidney failure, blindness, heart attacks and lower limb
amputation. Prevalence of diabetes is rising globally. α-glucosidase is validated target for …

[HTML][HTML] In-silico studies of some oxadiazoles derivatives as anti-diabetic compounds

MT Ibrahim, A Uzairu, GA Shallangwa… - Journal of King Saud …, 2020 - Elsevier
An in-silico study was performed to investigate the anti-diabetic activities of 27 Oxadiazoles
derivatives. The anti-diabetic compounds were optimized using Density Functional Theory …

Design, synthesis, biological evaluations and in silico studies of N-substituted 2, 4-thiazolidinedione derivatives as potential a-glucosidase inhibitors

L Dahiya, R Kumar, ATK Baidya, S Kumar… - Journal of …, 2023 - Taylor & Francis
Diabetes mellitus is considered as one of the principal global health urgencies of the twenty
first century. In the present investigation, novel N-substituted 2, 4-thiazolidinedione …

Alpha-glucosidase activity of novel pyrazolobenzothiazine 5, 5-dioxide derivatives for the treatment of diabetes mellitus. Invitro combined with molecular docking …

S Taj, UA Ashfaq, S Aslam, M Ahmad, SH Bhatti - Biologia, 2019 - Springer
Diabetes mellitus is a metabolic disease caused due to the improper secretion of insulin
which leads to hyperglycaemia. According to the International Diabetes Federation (IDF) …