PAMAM (polyamidoamine) dendrimers are commonly considered promising polymers that
can be successfully used in various biomedical applications. Nevertheless, direct clinical …

Poly (amidoamine)(PAMAM) dendrimers are the first complete dendrimer family to be
synthesized, characterized and commercialized. Based on this extensive activity, they are …

In this mini-review a number of novel outcomes, originating from studies in the field of
PAMAM dendrimers, are presented and discussed. Owing to the multi-disciplinary nature of …

First developed in the 1970s, dendrimers are a unique class of branched polymers with
characteristically low polydispersity making these materials attractive for a number of …

Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally
considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by …

Cancer is a killer disease second only to heart problems. 1 Though there is significant
progress in the field of anticancer technology, we are still badly in need of a reliable cure for …

Abstract Poly (amidoamine) dendrimers (PAMAM) are well-defined, highly branched,
nanoscale macromolecules with numerous active amine groups on the surface. PAMAM …

Drug solubility could affect the therapeutic use of a drug because the biological activity of a
drug is only possible if some fraction of a dissolved drug can permeate and overcome …

During the early 1980s, Donald A. Tomalia from the University of Michigan discovered a
unique 3D nano-architect providing a well-defined globular architect that he called …

For nearly a decade poly (amidoamine)(PAMAM) dendrimers G4 were claimed unnegligible
cytotoxic agents. Here we monitored whether in vivo cytotoxic effect of PAMAM G4 (0.5 …