Evaluation of alpha-II-spectrin breakdown products as potential biomarkers for early recognition and severity of aneurysmal subarachnoid hemorrhage

L Papa, K Rosenthal, F Silvestri, JC Axley, JM Kelly… - Scientific reports, 2018 - nature.com
This study assessed whether cytoskeletal protein alpha-II spectrin breakdown products
(SBDP150, SBDP145, and SBDP120) would identify the presence of aSAH and be …

Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury

SB Lewis, GJ Velat, L Miralia, L Papa, JM Aikman… - Journal of …, 2007 - thejns.org
Object Aneurysmal subarachnoid hemorrhage (ASAH) is a serious event with grave
consequences. Delayed ischemic neurological deficits caused by cerebral arterial …

Evidence that a panel of neurodegeneration biomarkers predicts vasospasm, infarction, and outcome in aneurysmal subarachnoid hemorrhage

R Siman, N Giovannone, N Toraskar, S Frangos… - PloS one, 2011 - journals.plos.org
Biomarkers for neurodegeneration could be early prognostic measures of brain damage and
dysfunction in aneurysmal subarachnoid hemorrhage (aSAH) with clinical and medical …

Neurofilament light chain and S100B serum levels are associated with disease severity and outcome in patients with aneurysmal subarachnoid hemorrhage

Z Zhou, J Zeng, S Yu, Y Zhao, X Yang, Y Zhou… - Frontiers in …, 2022 - frontiersin.org
Objectives Serum neurofilament light chain (NfL) is a biomarker for neuroaxonal damage,
and S100B is a blood marker for cerebral damage. In the present study, we investigated the …

αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients

S Mondello, SA Robicsek, A Gabrielli… - Journal of …, 2010 - liebertpub.com
In this study we assessed the clinical utility of quantitative assessments of αII-spectrin
breakdown products (SBDP145 produced by calpain, and SBDP120 produced by caspase …

Brain-specific biomarkers as mortality predictors after aneurysmal subarachnoid haemorrhage

J Kedziora, M Burzynska, W Gozdzik, A Kübler… - Journal of Clinical …, 2020 - mdpi.com
Aneurysmal subarachnoid haemorrhage (aSAH) is a serious condition with a high mortality
and high permanent disability rate for those who survive the initial haemorrhage. The …

Role of α-II-spectrin breakdown products in the prediction of the severity and clinical outcome of acute traumatic brain injury

S Chen, Q Shi, S Zheng, L Luo… - Experimental and …, 2016 - spandidos-publications.com
Abstract αII-spectrin breakdown products are regarded as potential biomarkers for traumatic
brain injury (TBI). The aim of the present study was to further evaluate these biomarkers by …

[HTML][HTML] Biomarkers in aneurysmal subarachnoid hemorrhage: A short review

S Batista, JE Bocanegra-Becerra, B Claassen… - World neurosurgery …, 2023 - Elsevier
Poor outcomes of aneurysmal subarachnoid hemorrhage (aSAH) can be the result of the
initial catastrophic event or the many acute or delayed neurological complications. Recent …

S100B, NSE and MMP-9 fail to predict neurologic outcome while elevated S100B associates with milder initial clinical presentation after aneurysmal subarachnoid …

H Kiiski, J Långsjö, J Tenhunen, M Ala-Peijari… - Journal of the …, 2018 - Elsevier
Objective Despite advances in the treatment of aneurysmal subarachnoid hemorrhage
(aSAH) one-year mortality remains approximately 50%. Making an accurate prognosis at the …

Markers of brain injury in patients with aneurysmal subarachnoid hemorrhage

J Fang, J Wang, Y Wang, Y Song - International Journal of …, 2024 - Taylor & Francis
Aim To investigate the correlation of serum changes and markers of brain injury (BI) in
cerebrospinal fluid (CSF) with postoperative cognitive dysfunction (POCD) in patients with …