Rapidly expanded activated human killer cell clones have strong antitumor cell activity and have the surface phenotype of either T gamma, T-non-gamma, or null cells.
RJ Van de Griend, BA Van Krimpen… - … (Baltimore, Md.: 1950 …, 1984 - journals.aai.org
Cloned lymphoid cell lines showing cytolytic activity were derived from natural killer (NK) cell-
enriched cell fractions obtained by fluorescence-activated cell sorting of cells that reacted …
enriched cell fractions obtained by fluorescence-activated cell sorting of cells that reacted …
Multiple activities of a cloned cell line mediating natural killer cell function.
G Nabel, LR Bucalo, J Allard, H Wigzell… - The Journal of …, 1981 - rupress.org
A special class of immunologic cells can lyse or damage a variety of target cells, notably
malignant cells in vitro. These cells have been called natural killer (NK) cells because lysis …
malignant cells in vitro. These cells have been called natural killer (NK) cells because lysis …
A novel type of human T cell clone with highly potent natural killer-like cytotoxicity divorced from large granular lymphocyte morphology.
EM Schneider, GP Pawelec, S Liangru… - Journal of immunology …, 1984 - journals.aai.org
Interleukin 2-dependent cloned lymphocytes derived from an allogeneic HLA class II-
mismatched but class I-matched mixed lymphocyte culture were screened for cytotoxic …
mismatched but class I-matched mixed lymphocyte culture were screened for cytotoxic …
Studies on natural killer (NK) cells. III. The effects of in vitro culture on spontaneous cytotoxicity of murine spleen cells.
SP Bartlett, RC Burton - Journal of immunology (Baltimore, Md …, 1982 - journals.aai.org
In vitro culture of normal lymphohemopoietic cells is a complex event leading to the
generation of a diverse group of effector cells. When murine spleen cells are cultured by …
generation of a diverse group of effector cells. When murine spleen cells are cultured by …
Cloned cell lines with natural killer activity. Specificity, function, and cell surface markers.
G Dennert, G Yogeeswaran, S Yamagata - The Journal of experimental …, 1981 - rupress.org
Cell lines with natural killer (NK) activity grown from native spleen cells cultured in medium
conditioned by spleen cells proliferating in the presence of concanavalin A (Con A) were …
conditioned by spleen cells proliferating in the presence of concanavalin A (Con A) were …
Assignment of human natural killer (NK)‐like cells to the T cell lineage. Single allospecific T cell clones lyse specific or NK‐sensitive target cells via distinct recognition …
A Moretta, G Pantaleo, MC Mingari… - European journal of …, 1984 - Wiley Online Library
The aim of the present study was to define the cell lineage of mixed lymphocyte culture
(MLC)‐induced natural killer (NK) effector cells. Human MLC cells were plated under limiting …
(MLC)‐induced natural killer (NK) effector cells. Human MLC cells were plated under limiting …
Mouse natural killer cells: induction specificity, and function
RM Welsh Jr - The Journal of Immunology, 1978 - journals.aai.org
Attention has recently focused on the possible significance of natural killer (NK) lymphocytes
in the surveillance of tumors by the immune system (1). This is because NK cells from …
in the surveillance of tumors by the immune system (1). This is because NK cells from …
In vitro generation of human activated lymphocyte killer cells: separate precursors and modes of generation of NK-like cells and" anomalous" killer cells.
GF Burns, T Triglia, JA Werkmeister - Journal of immunology …, 1984 - journals.aai.org
The activation of human peripheral blood mononuclear cells (PBM) in culture leads to the
generation of nonspecific killer cells. These cells, termed activated lymphocyte killer (ALK) …
generation of nonspecific killer cells. These cells, termed activated lymphocyte killer (ALK) …
Human natural killer cells, activated lymphocyte killer cells, and monocytes possess similar cytotoxic mechanisms.
GF Burns, T Triglia, PF Bartlett… - Proceedings of the …, 1983 - National Acad Sciences
The relationship between the killing mechanisms of human natural killer (NK) cells, mitogen-
and mixed-lymphocyte-culture-induced activated lymphocyte killer (ALK) cells, and …
and mixed-lymphocyte-culture-induced activated lymphocyte killer (ALK) cells, and …
Human natural killer cells: origin, clonality, specificity, and receptors
L Moretta, E Ciccone, MC Mingari, R Biassoni… - Advances in …, 1993 - Elsevier
Publisher Summary This chapter focuses on human natural killer (NK) cells. NK cells are
considered as effector cells that lyse tumor cells or virally infected cells via nonspecific …
considered as effector cells that lyse tumor cells or virally infected cells via nonspecific …