The wall teichoic acid and lipoteichoic acid polymers of Staphylococcus aureus

G Xia, T Kohler, A Peschel - International Journal of Medical Microbiology, 2010 - Elsevier
Staphylococci and most other Gram-positive bacteria incorporate complex teichoic acid (TA)
polymers into their cell envelopes. Several crucial roles in Staphylococcus aureus fitness …

Pathways and roles of wall teichoic acid glycosylation in Staphylococcus aureus

V Winstel, G Xia, A Peschel - International Journal of Medical Microbiology, 2014 - Elsevier
The thick peptidoglycan layers of Gram-positive bacteria are connected to polyanionic
glycopolymers called wall teichoic acids (WTA). Pathogens such as Staphylococcus aureus …

Wall teichoic acids of gram-positive bacteria

S Brown, JP Santa Maria Jr… - Annual review of …, 2013 - annualreviews.org
The peptidoglycan layers of many gram-positive bacteria are densely functionalized with
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial …

Teichoic acid biosynthesis as an antibiotic target

LW Pasquina, JP Santa Maria, S Walker - Current opinion in microbiology, 2013 - Elsevier
Highlights•Teichoic acids are conserved glycopolymers found in Gram-positive cell
envelopes.•LTA biosynthetic genes are essential and good targets for traditional …

A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps

S Brown, YH Zhang, S Walker - Chemistry & biology, 2008 - cell.com
Resistance to every family of clinically used antibiotics has emerged, and there is a pressing
need to explore unique antibacterial targets. Wall teichoic acids (WTAs) are anionic …

Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics

EWC Sewell, ED Brown - The Journal of antibiotics, 2014 - nature.com
Wall teichoic acids are a major and integral component of the Gram-positive cell wall. These
structures are present across all species of Gram-positive bacteria and constitute roughly …

Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS

D Lu, ME Wörmann, X Zhang… - Proceedings of the …, 2009 - National Acad Sciences
Staphylococcus aureus synthesizes polyglycerol-phosphate lipoteichoic acid (LTA) from
phosphatidylglycerol. LtaS, a predicted membrane protein with 5 N-terminal transmembrane …

Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM

G Xia, L Maier, P Sanchez-Carballo, M Li, M Otto… - Journal of Biological …, 2010 - ASBMB
Wall teichoic acid (WTA) glycopolymers are major constituents of cell envelopes in
Staphylococcus aureus and related Gram-positive bacteria with important roles in cell wall …

Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids

JP Santa Maria Jr, A Sadaka… - Proceedings of the …, 2014 - National Acad Sciences
Staphylococcus aureus contains two distinct teichoic acid (TA) polymers, lipoteichoic acid
(LTA) and wall teichoic acid (WTA), which are proposed to play redundant roles in regulating …

Lipoteichoic acid and lipids in the membrane of Staphylococcus aureus

W Fischer - Medical microbiology and immunology, 1994 - Springer
Lipoteichoic acids (LTAs), glycolipids and, less wide-spread, teichoic acids (TAs) are
characteristic components of the cell wall-membrane complex in a large group of gram …