An approach to detecting estrogenic endocrine disruption via choriogenin expression in an estuarine model fish species

SM Brander, BJ Cole, GN Cherr - Ecotoxicology, 2012 - Springer
A large body of work has established a link between endocrine disrupting compounds
(EDCs) and a number of abnormalities in fishes. However, most EDC studies use several …

Ecological risk assessment and testing for endocrine disruption in the aquatic environment

TH Hutchinson, DB Pickford - Toxicology, 2002 - Elsevier
Field observations of endocrine disruption (ED) in fish and other aquatic species have
contributed to a global effort to establish test methods for detecting ED effects in wildlife …

Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish

K Cheshenko, F Pakdel, H Segner, O Kah… - General and comparative …, 2008 - Elsevier
Many natural and synthetic compounds present in the environment exert a number of
adverse effects on the exposed organisms, leading to endocrine disruption, for which they …

Transcriptome alterations in zebrafish embryos after exposure to environmental estrogens and anti-androgens can reveal endocrine disruption

V Schiller, A Wichmann, R Kriehuber, C Schäfers… - Reproductive …, 2013 - Elsevier
Exposure to environmental chemicals known as endocrine disruptors (EDs) is in many
cases associated with an unpredictable hazard for wildlife and human health. The …

Screening and testing for endocrine disruption in fish—biomarkers as “signposts,” not “traffic lights,” in risk assessment

TH Hutchinson, GT Ankley, H Segner… - Environmental health …, 2006 - ehp.niehs.nih.gov
Biomarkers are currently best used as mechanistic “signposts” rather than as “traffic lights” in
the environmental risk assessment of endocrine-disrupting chemicals (EDCs). In field …

Gene expression responses in male fathead minnows exposed to binary mixtures of an estrogen and antiestrogen

N Garcia-Reyero, KJ Kroll, L Liu, EF Orlando… - BMC genomics, 2009 - Springer
Background Aquatic organisms are continuously exposed to complex mixtures of chemicals,
many of which can interfere with their endocrine system, resulting in impaired reproduction …

The estrogen receptor of the gastropod Nucella lapillus: modulation following exposure to an estrogenic effluent?

LFC Castro, C Melo, R Guillot, I Mendes, S Queirós… - Aquatic toxicology, 2007 - Elsevier
The molecular targets of estrogenic endocrine disrupting chemicals have been studied in
detail in vertebrates. The lack of basic endocrine knowledge impairs similar approaches for …

Bridging the gap from screening assays to estrogenic effects in fish: potential roles of multiple estrogen receptor subtypes

EE Yost, C Lee Pow, MB Hawkins… - … science & technology, 2014 - ACS Publications
This study seeks to delineate the ligand interactions that drive biomarker induction in fish
exposed to estrogenic pollutants and provide a case study on the capacity of human (h) …

Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project

H Segner, K Caroll, M Fenske, CR Janssen… - Ecotoxicology and …, 2003 - Elsevier
The EU-funded project IDEA aimed to evaluate (a) what parameters and endpoints allow the
detection of endocrine-mediated developmental and reproductive effects of (xeno) …

Twenty years of transcriptomics, 17alpha-ethinylestradiol, and fish

CJ Martyniuk, A Feswick, KR Munkittrick… - General and …, 2020 - Elsevier
In aquatic toxicology, perhaps no pharmaceutical has been investigated more intensely than
17alpha-ethinylestradiol (EE2), the active ingredient of the birth control pill. At the turn of the …