Cellular senescence is an initial barrier for carcinogenesis. However, the signaling
mechanisms that trigger cellular senescence are incompletely understood, particularly in …

Oncogene-induced senescence (OIS) is proposed as a cellular defense mechanism that
restrains malignant progression of oncogene-expressing, initiated tumor cells. Consistent …

Senescence is a tumor suppression mechanism that is induced by several stimuli, including
oncogenic signaling and telomere shortening, and controlled by the p53/p21WAF1 signaling …

KRAS is one of the most frequently mutated human oncogenes. In some settings, oncogenic
KRAS can trigger cellular senescence, whereas in others it produces hyperproliferation …

We have previously shown that W nt5 A drives invasion in melanoma. We have also shown
that W nt5 A promotes resistance to therapy designed to target the BRAF V600E mutation in …

Senescence, the irreversible cell cycle arrest of damaged cells, is accompanied by a
deleterious pro-inflammatory senescence-associated secretory phenotype (SASP) …

Critical cellular functions, including stem cell maintenance, fate determination, and cellular
behavior, are governed by canonical Wnt signaling, an evolutionarily conserved pathway …

Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy in the
United States. Thus, there is an urgent need to develop novel therapeutics for this disease …

Radiotherapy is routinely used for the treatment of lung cancer. However, the mechanisms
underlying ionizing radiation (IR)-induced senescence and its role in lung cancer treatment …

Cellular senescence is an irreversible proliferation arrest of primary cells and an important
tumor suppression process. Senescence is often characterized by domains of facultative …