Research on the postnatal development of pancreatic beta-cells has become an important
subject in recent years. Understanding the mechanisms that govern beta-cell postnatal …

Pancreatic β and α cells play essential roles in maintaining glucose homeostasis. However,
the mechanisms by which these distinct cell populations are generated, expand, and mature …

Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …

Aims/hypothesis Fetal and neonatal beta cells have poor glucose-induced insulin secretion
and only gain robust glucose responsiveness several weeks after birth. We hypothesise that …

Newly differentiated pancreatic β cells lack proper insulin secretion profiles of mature
functional β cells. The global gene expression differences between paired immature and …

Diabetes is a chronic and incurable disease, which results from absolute or relative insulin
insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses …

The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key
aspect of postnatal beta cell function. However, terminally differentiated beta cell identity …

Pancreatic β cell mass for appropriate blood glucose control is established during early
postnatal life. β cell proliferative capacity declines postnatally, but the extrinsic cues and …

Following differentiation during fetal development, β cells further adapt to their postnatal role
through functional maturation. While adult islets are thought to contain functionally mature β …

Introduction β-cell regeneration is an area under active investigation for the future treatment
of diabetes, but little is known about the patterns and dynamics of prenatal β-cell …