LIN28 is an RNA binding protein with important roles in early embryo development, stem cell
differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have …

In Caenorhabditis elegans, lin-4 and let-7 encode 22-and 21-nucleotide RNAs, respectively,
that function as key regulators of developmental timing. Because the appearance of these …

LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via
regulation of the microRNA let-7. However, recent studies have uncovered new roles for …

A hallmark of mammalian embryonic development is the widespread induction of microRNA
(miRNA) expression. Surprisingly, the transcription of many of these small, noncoding RNAs …

The highly conserved let-7 microRNA (miRNA) regulates developmental pathways across
animal phyla. Mis-expression of let-7 causes lethality in C. elegans and has been …

Development relies on the exquisite control of both the timing and the levels of gene
expression to achieve robust developmental transitions. How cis-and trans-acting factors …

ABSTRACT bHLH transcription factors function in neuronal development in organisms as
diverse as worms and vertebrates. In the C. elegans male tail, a neuronal sublineage …

The let-7 microRNA (miRNA) gene of Caenorhabditis elegans controls the timing of
developmental events. let-7 is conserved throughout bilaterian phylogeny and has multiple …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide.
Several studies have identified signature gene sets that may be useful as potential …

The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of
larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also …