Our appreciation of the significance of microRNAs to biology at large continues to be an
evolving process. The story began more than 15 years ago with the characterization of two …

Background Biological timing mechanisms that integrate cyclical and successive processes
are not well understood. C. elegans molting cycles involve rhythmic cellular and animal …

The developmentally regulated RNA-binding protein Lin28 blocks processing of let-7 family
microRNAs (miRNAs) in embryonic cells. The molecular basis for this selective miRNA …

Abstract The let-7 microRNA (miRNA) is an ultraconserved regulator of stem cell
differentiation and developmental timing and a candidate tumor suppressor. Here we show …

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

The conserved human LIN28 RNA-binding proteins function in development, maintenance
of pluripotency and oncogenesis. We used PAR-CLIP and a newly developed variant of this …

The homologous receptors LIN-12 and GLP-1 mediate diverse cell-signaling events during
development of the nematode Caenorhabditis elegans. These two receptors appear to be …

The RNA-binding protein (RBP) LIN41, also known as LIN-41 or TRIM71, is a key regulator
of animal development, but its physiological targets and molecular mechanism of action are …

Recently, genome-wide association studies have implicated the human LIN28B locus in
regulating height and the timing of menarche,,,,. LIN28B and its homolog LIN28A are …

Lin28 acts as a repressor of microRNA processing and as a post-transcriptional regulatory
factor for a subset of mRNAs. Here we report that in human embryonic stem cells Lin28 …