The evolution of our thinking about microRNAs
V Ambros - Nature medicine, 2008 - nature.com
Our appreciation of the significance of microRNAs to biology at large continues to be an
evolving process. The story began more than 15 years ago with the characterization of two …
evolving process. The story began more than 15 years ago with the characterization of two …
[HTML][HTML] LIN-42/PERIOD controls cyclical and developmental progression of C. elegans molts
GC Monsalve, C Van Buskirk, AR Frand - Current Biology, 2011 - cell.com
Background Biological timing mechanisms that integrate cyclical and successive processes
are not well understood. C. elegans molting cycles involve rhythmic cellular and animal …
are not well understood. C. elegans molting cycles involve rhythmic cellular and animal …
[HTML][HTML] Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28
E Piskounova, SR Viswanathan, M Janas… - Journal of Biological …, 2008 - ASBMB
The developmentally regulated RNA-binding protein Lin28 blocks processing of let-7 family
microRNAs (miRNAs) in embryonic cells. The molecular basis for this selective miRNA …
microRNAs (miRNAs) in embryonic cells. The molecular basis for this selective miRNA …
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
NJ Lehrbach, J Armisen, HL Lightfoot… - Nature structural & …, 2009 - nature.com
Abstract The let-7 microRNA (miRNA) is an ultraconserved regulator of stem cell
differentiation and developmental timing and a candidate tumor suppressor. Here we show …
differentiation and developmental timing and a candidate tumor suppressor. Here we show …
[HTML][HTML] Lin28: primal regulator of growth and metabolism in stem cells
N Shyh-Chang, GQ Daley - Cell stem cell, 2013 - cell.com
In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
The conserved human LIN28 RNA-binding proteins function in development, maintenance
of pluripotency and oncogenesis. We used PAR-CLIP and a newly developed variant of this …
of pluripotency and oncogenesis. We used PAR-CLIP and a newly developed variant of this …
lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)
S Christensen, V Kodoyianni, M Bosenberg… - …, 1996 - journals.biologists.com
The homologous receptors LIN-12 and GLP-1 mediate diverse cell-signaling events during
development of the nematode Caenorhabditis elegans. These two receptors appear to be …
development of the nematode Caenorhabditis elegans. These two receptors appear to be …
[HTML][HTML] LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms
F Aeschimann, P Kumari, H Bartake, D Gaidatzis, L Xu… - Molecular cell, 2017 - cell.com
The RNA-binding protein (RBP) LIN41, also known as LIN-41 or TRIM71, is a key regulator
of animal development, but its physiological targets and molecular mechanism of action are …
of animal development, but its physiological targets and molecular mechanism of action are …
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies
H Zhu, S Shah, N Shyh-Chang, G Shinoda… - Nature …, 2010 - nature.com
Recently, genome-wide association studies have implicated the human LIN28B locus in
regulating height and the timing of menarche,,,,. LIN28B and its homolog LIN28A are …
regulating height and the timing of menarche,,,,. LIN28B and its homolog LIN28A are …
Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
C Qiu, Y Ma, J Wang, S Peng, Y Huang - Nucleic acids research, 2010 - academic.oup.com
Lin28 acts as a repressor of microRNA processing and as a post-transcriptional regulatory
factor for a subset of mRNAs. Here we report that in human embryonic stem cells Lin28 …
factor for a subset of mRNAs. Here we report that in human embryonic stem cells Lin28 …