Persistent pain is a sequela of several neurological conditions with a primary immune basis,
such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury …

Nociceptive pain results from the detection of intense or noxious stimuli by specialized high-
threshold sensory neurons (nociceptors), a transfer of action potentials to the spinal cord …

We highlight current theories about peripheral neuropathic pain and show that progress in
management is contingent on targeting treatment not at the aetiological factors or the …

Neuropathic pain develops as a result of lesions or disease affecting the somatosensory
nervous system either in the periphery or centrally. Examples of neuropathic pain include …

The immune system has long been recognised important in pain regulation through
inflammatory cytokine modulation of peripheral nociceptive fibres. Recently, cytokine …

Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Cytotoxicity and consequent cell death pathways are a critical component of the immune
response to infection, disease or injury. While numerous examples of inflammation causing …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Allodynia (pain due to a stimulus that does not usually provoke pain) and hyperalgesia
(increased pain from a stimulus that usually provokes pain) are prominent symptoms in …