The serrated pathway of carcinogenesis has been the subject of intense investigation over
the past 2 decades, but many gaps in our understanding still need to be resolved. Serrated …

The serrated pathway to colorectal cancers (CRCs) is a significant pathway encompassing
five distinct types of lesions, namely hyperplastic polyps (HPs), sessile serrated lesions …

Sessile serrated polyps are a recently recognized type of neoplastic polyp that develops
along a molecular pathway different from that of conventional adenomas. While the clinical …

Colorectal polyps have been traditionally classified as either hyperplastic or adenomatous,
with only the latter progressing to carcinoma. However, it is now recognized that certain …

Serrated polyps have long been thought to lack malignant potential in the human
colorectum. However, identification of the serrated pathway to colorectal cancer based on …

Serrated polyps were once thought to have no clinical implications with regards to the
development of colorectal cancer (CRC). Over the past several years, published data have …

Until recently, all serrated polyps were classified simply as hyperplastic polyps and were
thought to represent benign lesions with no progression to malignancy. However, the …

Serrated polyps (SPs) were once considered benign, clinically unimportant lesions.
However, it is now recognized that through the serrated neoplasia pathway (SNP), SPs play …

Colorectal cancer (CRC) is a heterogeneous disorder than arises via multiple distinct
pathways, such as the serrated pathway, in which serrated polyps (including variants of …

Context Colorectal cancer is a heterogeneous disease resulting from different molecular
pathways of carcinogenesis. Recent data evaluating the histologic features and molecular …