Liquid chromatography–mass spectrometry methods for urinary biomarker detection in metabonomic studies with application to nutritional studies

C Legido‐Quigley, C Stella… - Biomedical …, 2010 - Wiley Online Library
The effects of sample preparation and chromatographic method differences on the
classification and recovery of metabolic biomarkers from UPLC‐MS measurements on urine …

Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Y Qi, Y Song, H Gu, G Fan, Y Chai - Mass Spectrometry in Metabolomics …, 2014 - Springer
Currently, liquid chromatography-mass spectrometry (LC-MS) is one of the most important
analytical technologies for detecting hundreds of metabolites in the field of metabolomics. A …

GC-MS profiling of urinary organic acids evaluated as a quantitative method

P Duez, A Kumps, Y Mardens - Clinical chemistry, 1996 - academic.oup.com
We assessed the quantitative performances of a classical method for profiling urinary
organic acids: ethyl acetate extraction/oxime-trimethylsilyl derivatization/GC-MS. Twenty …

Comparison of ion-pair chromatography and capillary zone electrophoresis for the assay of organic acids as markers of abnormal metabolism

SP Wang, CS Liao - Journal of Chromatography A, 2004 - Elsevier
The abnormal organic acids in urine are closely related with physiological metabolism. To
determinate the low-molecular-mass metabolites in human biological fluids, although there …

Determination of organic acids in urine by solid‐phase microextraction and gas chromatography–ion trap tandem mass spectrometry previous 'in sample'derivatization …

M Pacenti, S Dugheri, F Villanelli… - Biomedical …, 2008 - Wiley Online Library
A method for the determination of the organic acids directly in the urine employing
derivatization with trimethyloxonium tetrafluoroborate as a methylating agent and sequential …

Automated metabolic profiling analysis of urinary steroids by a gas chromatography mass spectrometry data system

JJ Vrbanac, CC Sweeley… - Biomedical Mass …, 1983 - Wiley Online Library
A computer system (MSSMET), using methylene unit retention indices for an off‐line reverse
library search analysis of selected ion chromatograms from gas‐liquid chromatographic …

Analysis of volatile organic compounds in human urine by headspace gas chromatography–mass spectrometry with a multipurpose sampler

HG Wahl, A Hoffmann, D Luft, HM Liebich - Journal of Chromatography A, 1999 - Elsevier
A multipurpose sampler (Gerstel MPS), designed for liquid large volume, gaseous and
headspace samples was used for the GC–MS analysis of organic volatiles in human urine …

Application of ethyl chloroformate derivatization for gas chromatography–mass spectrometry based metabonomic profiling

Y Qiu, M Su, Y Liu, M Chen, J Gu, J Zhang, W Jia - Analytica chimica acta, 2007 - Elsevier
A new combined gas chromatography and mass spectrometry (GC–MS) method has been
developed suitable for the urine sample treatment in aqueous phase with ethyl …

[HTML][HTML] Development and validation of a GC-FID method for diagnosis of methylmalonic acidemia

F Keyfi, A Varasteh - Reports of biochemistry & molecular biology, 2016 - ncbi.nlm.nih.gov
Background: Urinary organic acids are water-soluble intermediates and end products of the
metabolism of amino acids, carbohydrates, lipids, and a number of other metabolic …

Solid-phase analytical derivatization for gas-chromatography–mass-spectrometry-based metabolomics

E Takeo, R Sasano, S Shimma, T Bamba… - Journal of bioscience and …, 2017 - Elsevier
A novel derivatization method for gas chromatography/mass spectrometry (GC/MS)-based
metabolomics was developed, based on solid-phase analytical derivatization (SPAD) with …