Clinical update on head and neck cancer: molecular biology and ongoing challenges

E Alsahafi, K Begg, I Amelio, N Raulf, P Lucarelli… - Cell death & …, 2019 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Targeted therapy in head and neck cancer: an update on current clinical developments in epidermal growth factor receptor-targeted therapy and immunotherapies

J Moreira, A Tobias, MP O'Brien, M Agulnik - Drugs, 2017 - Springer
Most patients diagnosed with head and neck squamous cell carcinoma (HNSCC) will
present with locally advanced disease, requiring multimodality therapy. Despite this curative …

Molecular targeted therapies in head and neck cancer-An update of recent developements

M Goerner, TY Seiwert, H Sudhoff - Head & Neck Oncology, 2010 - Springer
Targeted therapies have made their way into clinical practice during the past decade. They
have caused a major impact on the survival of cancer patients in many areas of clinical …

Head and neck cancer: Current challenges and future perspectives

GR Bhat, RG Hyole, J Li - Advances in cancer research, 2021 - Elsevier
Head and neck cancers are a heterogeneous, aggressive and genetically complex
collection of malignancies of the oral cavity, nasopharynx, oropharynx, hypopharynx, larynx …

[HTML][HTML] Precision medicine approaches to overcome resistance to therapy in head and neck cancers

S Ortiz-Cuaran, J Bouaoud, A Karabajakian… - Frontiers in …, 2021 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most incident cancer
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …

Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives

S Ausoni, P Boscolo-Rizzo, B Singh… - Cancer and Metastasis …, 2016 - Springer
Despite improvements in functional outcomes attributable to advances in radiotherapy,
chemotherapy, surgical techniques, and imaging techniques, survival in head and neck …

Targeted therapies in squamous cell carcinoma of the head and neck

KA Gold, HY Lee, ES Kim - … International Journal of the …, 2009 - Wiley Online Library
Head and neck cancer is a challenging disease that is expected to account for greater than
500,000 new cases worldwide in 2008. Toxicity has impeded advances in chemotherapy …

Molecular therapy in head and neck oncology

J Bernier, SM Bentzen, JB Vermorken - Nature reviews Clinical …, 2009 - nature.com
Therapeutic management of locally advanced, recurrent and metastatic head and neck
squamous cell carcinoma (HNSCC) is often limited by a rather unfavorable efficacy and …

Application of molecular targeted therapies in the treatment of head and neck squamous cell carcinoma

P Kozakiewicz… - Oncology …, 2018 - spandidos-publications.com
Despite the development of standard therapies, including surgery, radiotherapy and
chemotherapy, survival rates for head and neck squamous cell carcinoma (HNSCC) have …

The molecular biology of head and neck cancer

CR Leemans, BJM Braakhuis, RH Brakenhoff - Nature reviews cancer, 2011 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco and alcohol
consumption and by infection with high-risk types of human papillomavirus (HPV). Tumours …