[HTML][HTML] Novel systemic treatment modalities including immunotherapy and molecular targeted therapy for recurrent and metastatic head and neck squamous cell …

S Ghosh, PA Shah, FM Johnson - International journal of molecular …, 2022 - mdpi.com
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers
worldwide. More than half of patients with HNSCC eventually experience disease …

[HTML][HTML] Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer

HK Byeon, M Ku, J Yang - Experimental & molecular medicine, 2019 - nature.com
Epidermal growth factor receptor (EGFR) overexpression is common in head and neck
squamous cell carcinoma. Targeted therapy specifically directed towards EGFR has been …

Current and potential inflammation targeted therapies in head and neck cancer

F Wang, P Arun, J Friedman, Z Chen… - Current opinion in …, 2009 - Elsevier
Inflammation often exists in the tumor microenvironment and is induced by inflammatory
mediators (cytokines, chemokines, and growth factors) produced by the tumor, stroma, and …

The expanding role of systemic therapy in head and neck cancer

EEW Cohen, MW Lingen, EE Vokes - Journal of clinical oncology, 2004 - ascopubs.org
Treatment of squamous cell carcinoma of the head and neck (SCCHN) has evolved greatly
in the last two decades, owing to the integration of chemotherapy, advances in …

[HTML][HTML] Therapeutic approaches for the treatment of head and neck squamous cell carcinoma–An update on clinical trials

B Goel, AK Tiwari, RK Pandey, AP Singh, S Kumar… - Translational …, 2022 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin
cancer with a tobacco consumption and infection with high-risk human papillomavirus (HPV) …

New therapies in head and neck cancer

RT Santuray, DE Johnson, JR Grandis - Trends in cancer, 2018 - cell.com
Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with high rates
of mortality and morbidity. Beginning with cetuximab, investigators continue to optimize …

Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice

CA Glazer, SS Chang, PK Ha, JA Califano - Oral oncology, 2009 - Elsevier
During the past decade, there has been a significant increase in knowledge regarding the
molecular biology and epigenetics of head and neck squamous cell carcinoma (HNSCC) …

Novel prognostic clinical factors and biomarkers for outcome prediction in head and neck cancer: a systematic review

V Budach, I Tinhofer - The Lancet Oncology, 2019 - thelancet.com
Current algorithms for the clinical management of patients with squamous cell carcinoma of
the head and neck (HNSCC) are based on a stage-dependent strategy where all patients at …

The molecular landscape of head and neck cancer

CR Leemans, PJF Snijders, RH Brakenhoff - Nature Reviews Cancer, 2018 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …

[HTML][HTML] Epigenetic modifications and head and neck cancer: implications for tumor progression and resistance to therapy

RM Castilho, CH Squarize, LO Almeida - International journal of …, 2017 - mdpi.com
Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …