Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck

DR Simpson, LK Mell, EEW Cohen - Oral oncology, 2015 - Elsevier
Despite recent advances in novel therapies, the prognosis for patients with squamous cell
carcinoma of the head and neck (SCCHN) remains poor. Progress in understanding the …

[HTML][HTML] Head and neck squamous cell carcinoma

DE Johnson, B Burtness, CR Leemans… - Nature reviews Disease …, 2020 - nature.com
Most head and neck cancers are derived from the mucosal epithelium in the oral cavity,
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …

Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies

F Pezzuto, L Buonaguro, F Caponigro, F Ionna… - Oncology, 2015 - karger.com
Tobacco use and alcohol consumption are the main risk factors associated with head and
neck squamous cell carcinoma (SCC) development due to their cytotoxic and mutagenic …

[HTML][HTML] Targeting the immune microenvironment in the treatment of head and neck squamous cell carcinoma

HC Wang, LP Chan, SF Cho - Frontiers in Oncology, 2019 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive solid tumor, with
a 5-year mortality rate of~ 50%. The development of immunotherapies has improved the …

[HTML][HTML] Updated overview of current biomarkers in head and neck carcinoma

K Dahiya, R Dhankhar - World journal of methodology, 2016 - ncbi.nlm.nih.gov
Squamous cell cancer is the most common type of malignancy arising from the epithelial
cells of the head and neck region. Head and neck squamous cell carcinoma (HNSCC) is …

Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)-and ErbB family-targeted agents in the treatment of head and neck …

RB Cohen - Cancer treatment reviews, 2014 - Elsevier
Overexpression of the epidermal growth factor receptor (EGFR) is a common characteristic
of head and neck squamous cell carcinomas (HNSCC). Cetuximab is a chimeric anti-EGFR …

[HTML][HTML] Advances in the management of squamous cell carcinoma of the head and neck

JP Machiels, M Lambrecht, FX Hanin, T Duprez… - F1000prime …, 2014 - ncbi.nlm.nih.gov
Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer
worldwide. The main risk factors for cancers of the oral cavity, larynx, oropharynx, and …

[HTML][HTML] Immunotherapies and future combination strategies for head and neck squamous cell carcinoma

V Cristina, RG Herrera-Gómez, P Szturz… - International journal of …, 2019 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced
stage and has a dismal prognosis. Nearly 10 years after the approval of cetuximab, anti …

Head and neck cancer: past, present and future

D Chin, GM Boyle, S Porceddu, DR Theile… - Expert review of …, 2006 - Taylor & Francis
Head and neck cancer consists of a diverse group of cancers that ranges from cutaneous,
lip, salivary glands, sinuses, oral cavity, pharynx and larynx. Each group dictates different …

[HTML][HTML] HPV positive head and neck cancers: molecular pathogenesis and evolving treatment strategies

R Dok, S Nuyts - Cancers, 2016 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that
is the result of tobacco and/or alcohol abuse or infection with high-risk Human …