Even more intriguing was the finding that central or peripheral administration of the
endocannabinoid anandamide determines overfeeding in rodents, confirming a direct role …

Abdominal obesity is a prevalent, worldwide problem linked to cardiometabolic
comorbidities and an increased risk of coronary heart disease. First-line therapy to reduce …

Several cardiometabolic factors present in obese and insulin-resistant individuals represent
a continuum of increasing risk for the development of type 2 diabetes and cardiovascular …

The endocannabinoid system (ECS) is a signalling cascade consisting of CB1 and CB2
receptors, and enzymes for the synthesis and degradation of endogenous ligands for these …

The role played by the endocannabinoid system in the regulation of energy balance is
currently generating a great amount of interest among several groups of investigators. This …

The endocannabinoid system has emerged as a significant player in the control of energy
balance and metabolism, through its direct central and peripheral effects, as well as via its …

Background The endocannabinoids, anandamide and 2-AG, are produced by adipocytes,
where they stimulate lipogenesis via cannabinoid CB 1 receptors and are under the …

Endocannabinoids (ECs) are small lipid mediators that play a critical role in energy
metabolism. Human studies have shown that the EC tone in peripheral tissues positively …

There is an urgent need for developing effective drugs to combat the obesity and Type 2
diabetes mellitus epidemics. The endocannabinoid system plays a major role in energy …

The cannabinoid receptors for Δ 9-THC, and particularly, the CB 1 receptor, as well as its
endogenous ligands, the endocannabinoids anandamide and 2-arachidonoylglycerol, are …