N-Acetylglucosamine and its dimer ameliorate inflammation in murine colitis by strengthening the gut barrier function

SI Choi, YC Shin, JS Lee, YC Yoon, JM Kim… - Food & Function, 2023 - pubs.rsc.org
Ulcerative colitis (UC) is a chronic gastrointestinal disease whose incidence is increasing
rapidly worldwide. Anti-inflammatory medications, including 5-aminosalicylic acid (5-ASA) …

Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats

S Yomogida, Y Kojima… - International …, 2008 - spandidos-publications.com
Glucosamine, a naturally occurring amino monosaccharide, is widely used to treat
osteoarthritis in humans. Furthermore, glucosamine exhibits an anti-inflammatory action by …

Effects of dietary supplementation of glucosamine sulfate on intestinal inflammation in a mouse model of experimental colitis

YK Bak, JW Lampe, MK Sung - Journal of gastroenterology and …, 2014 - Wiley Online Library
Abstract Background and Aim Epidemiological evidences suggested an inverse association
between the use of glucosamine supplements and colorectal cancer (CRC) risk. In this …

Higenamine improves DSS-induced ulcerative colitis in mice through the Galectin-3/TLR4/NF-κB pathway

X Shao, Y Xu, H Xiao, Y Hu, Y Jiang - Tissue and Cell, 2023 - Elsevier
Ulcerative colitis (UC) is an inflammatory disease of the colon and tends to relapse.
Higenamine (HG) has anti-inflammatory, antioxidant and anti-apoptotic activities. This study …

Gallic acid ameliorates colitis by trapping deleterious metabolite ammonia and improving gut microbiota dysbiosis

J Peng, T Liu, P Meng, Y Luo, S Zhu, Y Wang, M Ma… - Mbio, 2024 - Am Soc Microbiol
Gut microbiota dysbiosis is causally related to inflammatory bowel disease (IBD), and
increased levels of the gut metabolite ammonia have been proposed to contribute to IBD …

Dietary bioactive peptide alanyl‐glutamine attenuates dextran sodium sulfate‐induced colitis by modulating gut microbiota

Q Xu, M Hu, M Li, J Hou, X Zhang, Y Gao… - Oxidative medicine …, 2021 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic intestinal disorder threatening human health.
Di‐peptide alanyl‐glutamine (Ala‐Gln) has various beneficial effects on gut health …

Pre-clinical investigation of protective effect of nutraceutical D-glucosamine on TNBS-induced colitis

S Roy, S Dhaneshwar, T Mahmood… - …, 2023 - Taylor & Francis
Objective The level of precursors involved in the biosynthesis of glycosaminoglycan (GAG),
glucosamine synthase, and N-acetyl glucosamine (NAG), are significantly reduced in …

Cyclic nigerosylnigerose ameliorates DSS-induced colitis with restoration of goblet cell number and increase in IgA reactivity against gut microbiota in mice

T Tsuruta, E Katsumata, A Mizote, HJ Jian… - … of microbiota, food …, 2020 - jstage.jst.go.jp
Cyclic nigerosylnigerose (CNN) is a cyclic oligosaccharide. Oral administration of CNN
promotes immunoglobulin A (IgA) secretion in the gut. IgA is a major antibody secreted into …

[HTML][HTML] N-Acetylglucosamine for Treatment of Inflammatory Bowel Disease

A Zhu, I Patel, M Hidalgo, V Gandhi - Nat. Med. J, 2015 - naturalmedicinejournal.com
Background: Inflammatory bowel disease (IBD) is associated with a widespread breakdown
of glycosaminoglycans, which are normally attached to mucin and help to form a protective …

[HTML][HTML] Mannose enhances intestinal immune barrier function and dextran sulfate sodium salt-induced colitis in mice by regulating intestinal microbiota

Y Yang, Q Ma, Q Wang, L Zhao, H Liu… - Frontiers in …, 2024 - frontiersin.org
Background Inflammatory bowel disease (IBD) greatly affects human quality of life. Mannose
has been reported to be used to treat IBD, but the mechanism is currently unknown. Methods …