Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc

Y Zhang, J Gao, Y Xu, J Liu, S Huang, G Li… - Phytotherapy …, 2022 - Wiley Online Library
Deoxyshikonin, a natural naphthoquinone compound extracted from Lithospermum
erythrorhizon Sieb. et Z ucc (Boraginaceae), has a wide range of pharmacological activities …

Acetylshikonin is a novel non‐selective cytochrome P450 inhibitor

JC Shon, NM Phuc, WC Kim, JK Heo… - … & Drug Disposition, 2017 - Wiley Online Library
Acetylshikonin is a biologically active compound with anti‐cancer and anti‐inflammatory
activity, which is isolated from the roots of Lithospermum erythrorhizoma. An inhibitory effect …

Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay

S Tang, A Chen, X Zhou, L Zeng, M Liu, X Wang - Toxicology Letters, 2017 - Elsevier
Shikonin is a naphthoquinone pigment extracted from roots of Lithospermum erythrorhizon
Sieb. et Zucc.(Boraginaceae), and possesses various pharmaceutical activities, such as anti …

Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells

SH Park, NM Phuc, J Lee, Z Wu, J Kim, H Kim… - Phytomedicine, 2017 - Elsevier
Background Acetylshikonin is one of the biologically active compounds derived from the root
of Lithospermum erythrorhizon, a medicinal plant with anti-cancer and anti-inflammation …

Strong and selective inhibitory effects of the biflavonoid selamariscina A against CYP2C8 and CYP2C9 enzyme activities in human liver microsomes

SY Park, PH Nguyen, G Kim, SN Jang, GH Lee… - Pharmaceutics, 2020 - mdpi.com
Like flavonoids, biflavonoids, dimeric flavonoids, and polyphenolic plant secondary
metabolites have antioxidant, antibacterial, antiviral, anti-inflammatory, and anti-cancer …

Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method

J Gao, Y Zhang, X Lei, Y Xu, Z Sun, X Wang - Toxicology in Vitro, 2022 - Elsevier
Hydroxygenkwanin (HGK), a natural flavonoid extracted from the buds of Daphne genkwa
Sieb. et Zucc.(Thymelaeaceae), possesses a wide range of pharmacological activities …

Potent inhibitory effect of alpha-viniferin on human cytochrome P450

J Sim, HW Jang, M Song, JH Kim, SH Lee… - Food and chemical …, 2014 - Elsevier
Abstract α-Viniferin isolated from Caragana chamlagu is a trimer of resveratrol, and has
several biological activities, which include anti-inflammatory, anti-oxidant, anti-arthritis, and …

In vitro inhibition of human cytochrome P450 enzymes by licoisoflavone B from Glycyrrhiza uralensis Fisch. ex DC

L Chen, D Nikolic, G Li, J Liu… - Toxicological …, 2023 - academic.oup.com
Glycyrrhiza uralensis Fisch. ex DC, one of the 3 pharmacopeial species of licorice and
widely used in dietary supplements, can inhibit certain cytochrome P450 (CYP) enzymes …

Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme

J Lu, D Liu, X Zhou, A Chen, Z Jiang, X Ye, M Liu… - Phytomedicine, 2018 - Elsevier
Abstract Background Cytochrome P450 2J2 (CYP2J2) is not only highly expressed in many
kinds of human tumors, but also promotes tumor cell growth via regulating the metabolism of …

Selective Inhibition of Bakuchicin Isolated from Psoralea corylifolia on CYP1A in Human Liver Microsomes

SJ Kim, HC Oh, YC Kim, GS Jeong… - … and Alternative Medicine, 2016 - Wiley Online Library
Bakuchicin is a furanocoumarin isolated from Psoralea corylifolia and shows several
biological activities. Although there have been studies on the biological effects of …