Berberine suppresses adipocyte differentiation via decreasing CREB transcriptional activity

J Zhang, H Tang, R Deng, N Wang, Y Zhang, Y Wang… - PLoS one, 2015 - journals.plos.org
Berberine, one of the major constituents of Chinese herb Rhizoma coptidis, has been
demonstrated to lower blood glucose, blood lipid, and body weight in patients with type 2 …

Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARγ pathway

C Huang, Y Zhang, Z Gong, X Sheng, Z Li… - Biochemical and …, 2006 - Elsevier
Berberine (BBR), a compound purified from Cortidis rhizoma, reduces serum cholesterol,
triglycerides, and LDL-cholesterol of hypercholesterolemic patients and high fat diet fed …

Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2

TPT Pham, J Kwon, J Shin - Biochemical and biophysical research …, 2011 - Elsevier
Berberine exerts an anti-adipogenic activity that is associated with the down-regulation of
C/EBPα and PPARγ. Stimulation of AMP-activated kinase (AMPK) caused by inhibition of …

Berberine regulates peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in diabetic adipocytes

J Zhou, S Zhou - European Journal of Pharmacology, 2010 - Elsevier
Berberine has hypoglycemic and hypolipidemic effects on diabetic rats. This study
investigated the relationship between hypoglycemic and hypolipidemic effects of berberine …

Berberine reduces lipid accumulation in obesity via mediating transcriptional function of PPARδ

JW Shou, PC Shaw - International Journal of Molecular Sciences, 2023 - mdpi.com
Obesity is defined as a dampness-heat syndrome in traditional Chinese medicine. Coptidis
Rhizoma is an herb used to clear heat and eliminate dampness in obesity and its …

Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways

JS Choi, JH Kim, MY Ali, HJ Jung, BS Min… - Archives of pharmacal …, 2015 - Springer
It has been reported that alkaloids derived from Coptis chinensis exert anti-adipogenic
activity on 3T3-L1 adipocytes by downregulating peroxisome proliferation-activity receptor-γ …

Berberine inhibits adipogenesis in high-fat diet-induced obesity mice

Y Hu, GE Davies - Fitoterapia, 2010 - Elsevier
Our previous studies illustrated that berberine inhibited adipogenesis in murine-derived 3T3-
L1 preadipocytes and human white preadipocytes. In this study, the effects of berberine on …

13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells

YL Chow, M Sogame, F Sato - Scientific reports, 2016 - nature.com
Lipid metabolism modulation is a main focus of metabolic syndrome research, an area in
which many natural and synthetic chemicals are constantly being screened for in vitro and in …

Effect of berberine on the differentiation of adipocyte

LB Zhou, MD Chen, X Wang, HD Song… - Zhonghua yi xue za …, 2003 - europepmc.org
Objective To observe the effect of berberine on the differentiation of 3T3-L1 preadipocytes
into adipocytes and to elucidate its mechanism. Methods 3T3-L1 preadipocytes were …

Berberine modulates gut microbiota and reduces insulin resistance via the TLR4 signaling pathway

D Liu, Y Zhang, Y Liu, L Hou, S Li… - Experimental and …, 2018 - thieme-connect.com
Berberine, a natural compound extracted from several Chinese herbs including Coptis
chinensis, has been shown to have anti-obesity effects and prevents insulin resistance in …