Members of the major histocompatibility complex (MHC) class I family of proteins are well
known for their central role in the adaptive immune system, where they present self and non …

For the nervous system to translate experience into memory and behavior, lasting structural
change at synapses must occur. This requirement is clearly evident during critical periods of …

Immune molecules have been discovered recently to play critical roles in the development,
function, and plasticity of the cerebral cortex. MHC class I (MHCI) molecules are expressed …

Proper development of the central nervous system (CNS) requires the establishment of
appropriate connections between neurons. Recent work suggests that this process is …

Class I major histocompatibility complex (class I MHC) molecules, known to be important for
immune responses to antigen, are expressed also by neurons that undergo activity …

Research has long supported the view that the brain is immunologically privileged, in part
because normal, uninfected neurons were not thought to express major histocompatibility …

Mice deficient in classical major histocompatibility complex class I (MHCI) have aberrations
in neurodevelopment. The consequences of upregulated neuronal MHCI expression have …

Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where
they regulate synaptic plasticity. However, the mechanisms by which MHC-I functions in the …

Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent
refinement and plasticity. We found that MHCI also negatively regulates the density and …

MHC antigens count among the classical ''immune''molecules. They act as platforms
presenting antigenic peptides to the specific receptors on T cells. MHC class I molecules …