Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …

Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized
by the progressive destruction of articular cartilage, synovial inflammation, changes in …

Osteoarthritis (OA) is the most common form of joint disease. Histopathologically, OA is
characterized by a progressive loss of articular cartilage, osteophyte formation, thickening of …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

Osteoarthritis (OA) can be a progressive, disabling disease, leading to diminished quality of
life, and, for over 500,000 individuals annually in the US, total joint replacement. The …

Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …

Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of
the articular cartilage, subchondral bone alterations and synovitis. Current treatments are …

Highlights•Osteoarthritis (OA) is a common and debilitating disease with no effective
treatments.•Articular chondrocyte behavior and matrix maintenance are major targets.•The …

Great progress continues to be made in our understanding of the multiple facets of
osteoarthritis (OA) biology. Here, we review the major advances in this field and progress …