Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis
Y Wei, L Bai - Connective tissue research, 2016 - Taylor & Francis
Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …
morbidity. It is predicted to be the single greatest cause of disability in the general population …
[HTML][HTML] Therapeutics in osteoarthritis based on an understanding of its molecular pathogenesis
JR Kim, JJ Yoo, HA Kim - International journal of molecular sciences, 2018 - mdpi.com
Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized
by the progressive destruction of articular cartilage, synovial inflammation, changes in …
by the progressive destruction of articular cartilage, synovial inflammation, changes in …
Molecular regulation of articular chondrocyte function and its significance in osteoarthritis
JP Schroeppel, JD Crist, HC Anderson… - … and histopathology, Vol …, 2011 - digitum.um.es
Osteoarthritis (OA) is the most common form of joint disease. Histopathologically, OA is
characterized by a progressive loss of articular cartilage, osteophyte formation, thickening of …
characterized by a progressive loss of articular cartilage, osteophyte formation, thickening of …
Emerging targets in osteoarthritis therapy
MB Goldring, F Berenbaum - Current opinion in pharmacology, 2015 - Elsevier
Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …
Prospects for disease modification in osteoarthritis
SB Abramson, M Attur, Y Yazici - Nature Clinical Practice …, 2006 - nature.com
Osteoarthritis (OA) can be a progressive, disabling disease, leading to diminished quality of
life, and, for over 500,000 individuals annually in the US, total joint replacement. The …
life, and, for over 500,000 individuals annually in the US, total joint replacement. The …
[HTML][HTML] Cartilage and bone destruction in arthritis: pathogenesis and treatment strategy: a literature review
D Tateiwa, H Yoshikawa, T Kaito - Cells, 2019 - mdpi.com
Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …
[HTML][HTML] Osteoarthritis: a narrative review of molecular approaches to disease management
Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …
New molecular targets for the treatment of osteoarthritis
MJ Alcaraz, J Megías, I García-Arnandis… - Biochemical …, 2010 - Elsevier
Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of
the articular cartilage, subchondral bone alterations and synovitis. Current treatments are …
the articular cartilage, subchondral bone alterations and synovitis. Current treatments are …
[HTML][HTML] New developments in osteoarthritis and cartilage biology
B Poulet, KA Staines - Current opinion in pharmacology, 2016 - Elsevier
Highlights•Osteoarthritis (OA) is a common and debilitating disease with no effective
treatments.•Articular chondrocyte behavior and matrix maintenance are major targets.•The …
treatments.•Articular chondrocyte behavior and matrix maintenance are major targets.•The …
[HTML][HTML] Osteoarthritis year in review 2023: Biology
AJ Roelofs, C De Bari - Osteoarthritis and cartilage, 2023 - Elsevier
Great progress continues to be made in our understanding of the multiple facets of
osteoarthritis (OA) biology. Here, we review the major advances in this field and progress …
osteoarthritis (OA) biology. Here, we review the major advances in this field and progress …