Activated CD4 Th1 lymphocytes can enter the brain in the absence of an inflammatory focus.
However, the molecular mediators that regulate this early migration of lymphocytes into the …

Clonally expanded CD8+ T lymphocytes are present in multiple sclerosis lesions, as well as
in the cerebrospinal fluid of patients with multiple sclerosis. In experimental autoimmune …

Lymphocyte migration into the brain represents a critical event in the pathogenesis of
multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE) …

Lymphocyte recruitment into the brain is a critical event in the pathogenesis of multiple
sclerosis and experimental autoimmune encephalomyelitis. We developed a novel intravital …

Endothelial cells of the blood-brain barrier (BBB) have the ability to regulate and restrict the
passage of cells and molecules from the periphery to the CNS. We have used an in vitro …

CD8 T cells are nature's foremost defense in encephalitis and brain tumors. Antigen-specific
CD8 T cells need to enter the brain to exert their beneficial effects. On the other hand, traffic …

The CNS is an immune-privileged environment, yet the local control of multiple pathogens is
dependent on the ability of immune cells to access and operate within this site. However …

Although the blood–brain barrier and blood cerebrospinal fluid barrier maintain the central
nervous system (CNS) as an immunologically privileged site, T lymphocytes can migrate …

Central nervous system (CNS) homeostasis is a prerequisite for the proper communication
of neuronal cells. To this end, the endothelial blood–brain barrier (BBB) and the epithelial …

Lymphocyte recruitment to the central nervous system (CNS) is a critical step in the
pathogenesis of diseases such as multiple sclerosis (MS), meningitis and posterior uveitis …